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Synthesis and studies of calcium channel blocking and antioxidant activities of...
Rucins, Martins; Kaldre, Dainis; Pajuste, Karlis; Fernandes, Maria A. S.; Vicente, Joaquim A. F.; Klimaviciusa, Linda; Jaschenko, ElinaThe novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at the position 4, and the N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle were designed, synthesised, and assessed in biological tests. Among all the novel compounds, the 4-(N-dodecyl) pyridinium group-containing compounds 11 (without the N-propargyl group) and 12 (with the N-propargyl group) demonstrated th...
Mitochondria as the target for mildronate's protective effects in azidothymidin...
Pupure, Jolanta; Fernandes, Maria A. S.; Santos, Maria S.; Moreno, António J. M.; Kalvinsh, Ivars; Klusa, Vija; Oliveira, Catarina R.Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardiotoxicity model in vivo (in mice), we have found mildronate's ability of protecting heart tissu...
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