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Group B Streptococcus Hijacks the Host Plasminogen System to Promote Brain Endo...
Magalhães, V.; Andrade, E.; Alves, J.; Ribeiro, A:; Kim, K.; Lima, M.; Trieu-Cuot, P.; Ferreira, P.Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial virulence. Here, we investigated whether plasmin(ogen) bound at the GBS surface contributes to blood-brain barrier penetration and invasion of the central nervous s...
Quantum tunneling in biological reactions: the interplay between theory and exp...
Onuchic,José N.; Kobayashi,Chigusa; Baldridge,Kim K.Ricardo Ferreira was the first Brazilian scientist to understand the need of solid theoretical approaches to obtain quantitative understanding mechanisms governing the life sciences. Therefore, in this issue in his honor, we decided to describe how theory has been able to guide the understanding of electron tunneling in biology. During almost twenth years, our Pathway model has been the most powerful model in t...
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