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Biological evaluation of intervertebral disc cells in different formulations of...
Khang, G.; Lee, S. K.; Kim, H. N.; Silva-Correia, J.; Gomes, Manuela E.; Viegas, C. A. A.; Dias, Isabel R.; Oliveira, Joaquim M.; Reis, R. L.Gellan gum (GG)-based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine-tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formula...
Evaluation of different formulations of gellan gum-based hydrogels for tissue e...
Lee, S. K.; Correia, Joana Silva; Caridade, S. G.; Mano, J. F.; Oliveira, Joaquim M.; Khang, G.; Reis, R. L.Gellan gum based-hydrogels present advantageous features for application as acellular and cellular nucleus pulposus (NP) substitutes due to the possibility of fine-tuning its physico-chemical and biological properties. In this study, ionic-crosslinked hydrogel discs were produced by means of mixing a raw and chemically modified material, i.e., high acyl gellan gum (HAGG) and methacrylated low acyl gellan gum (G...
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