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Nanostructured 3D constructs based on chitosan and chondroitin sulphate multila...
Silva, Joana M.; Georgi, N.; Costa, Rui; Praveen, S.; Reis, R. L.; Blitterswijk, C. A. van; Karperien, M.; Mano, J. F.Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositing the polyelectrolytes chitosan (CHT) and chondroitin sulphate (CS) on either bidimensional glass surfaces or 3D packet of paraffin spheres. 2D CHT/CS multi-layered...
Chitosan/Poly(ε-caprolactone) blend scaffolds for cartilage repair
Neves, S. C.; Teixeira, L. S. Moreira; Moroni, L.; Reis, R. L.; Blitterswijk, C. A. van; Alves, N. M.; Karperien, M.; Mano, J. F.Chitosan (CHT)/poly(ε-caprolactone) (PCL) blend 3D fiber-mesh scaffolds were studied as possible support structures for articular cartilage tissue (ACT) repair. Micro-fibers were obtained by wet-spinning of three different polymeric solutions: 100:0 (100CHT), 75:25 (75CHT) and 50:50 (50CHT) wt.% CHT/PCL, using a common solvent solution of 100 vol.% of formic acid. Scanning electron microscopy (SEM) analysis sho...
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