Encontrados 5 documentos, a visualizar página 1 de 1
Diabetes induces early transient changes in the content of vesicular transporte...
Baptista, Filipa I.; Gaspar, Joana M.; Cristóvão, Armando; Santos, Paulo F.; Köfalvi, Attila; Ambrósio, António F.Diabetes induces changes in neurotransmitter release in central nervous system, which depend on the type of neurotransmitter and region studied. In this study, we evaluated the effect of diabetes (two and eight weeks duration) on basal and evoked release of [14C]glutamate and [3H]GABA in hippocampal and retinal synaptosomes. We also analyzed the effect of diabetes on the protein content of vesicular glutamate a...
N-acyldopamines control striatal input terminals via novel ligand-gated cation ...
Ferreira, Samira G.; Lomaglio, Tonia; Avelino, Antonio; Cruz, Francisco; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, Attilahttp://www.sciencedirect.com/science/article/B6T0C-4V3HHM3-1/2/22d594101b6927eca47e1b39b53ffcee
Modification upon aging of the density of presynaptic modulation systems in the...
Canas, Paula M.; Duarte, João M. N.; Rodrigues, Ricardo J.; Köfalvi, Attila; Cunha, Rodrigo A.Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve te...
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotoc...
Duarte, João M. N.; Nogueira, Célia; Mackie, Ken; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, AttilaIn the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB1R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, ...
Differential glutamate-dependent and glutamate-independent adenosine A1 recepto...
Borycz, Janusz; Pereira, M. Fátima; Melani, Alessia; Rodrigues, Ricardo J.; Köfalvi, Attila; Panlilio, Leigh; Pedata, Felicita; Goldberg, Steven R.Adenosine and dopamine are two important modulators of glutamatergic neurotransmission in the striatum. However, conflicting reports exist about the role of adenosine and adenosine receptors in the modulation of striatal dopamine release. It has been previously suggested that adenosine A1 receptors localized in glutamatergic nerve terminals indirectly modulate dopamine release, by their ability to modulate glut...
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