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Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippoca...

Studies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out a detailed morphometric analysis of the hippo...

How repeated and unpredictable experiences turn into fear-memories

Dopaminergic modulation of affective and social deficits induced by prenatal gl...

Prenatal stress or exposure to elevated levels of glucocorticoids (GCs) can impair specific neurobehavioral circuits leading to alterations in emotional processes later in life. In turn, emotional deficits may interfere with the quality and degree of social interaction. Here, by using a comprehensive behavioral approach in combination with the measurement of ultrasonic vocalizations, we show that in utero GC (i...

The bed nucleus of stria terminalis and the amygdala as targets of antenatal gl...

Rationale: Several human and experimental studies have shown that early life adverse events can shape physical and mental health in adulthood. Stress or elevated levels of glucocorticoids (GCs) during critical periods of development seem to contribute for the appearance of neurospyschiatric conditions such as anxiety and depression, albeit the underlying mechanisms remain to be fully elucidated. Objectives: The...

Atividade farmacológica da monocrotalina isolada de plantas do gênero Crotalaria

Crotalaria retusa é uma planta encontrada no Nordeste brasileiro, pertence ao gênero Crotalaria e à família Leguminosae, e possuem mais de seissentas espécies no mundo e mais de quarenta no Brasil. As variedades tóxicas mais conhecidas são C. spectabilis, C. crispata, C. retusa, C. dura e C. globifera. Plantas do gênero Crotalaria são de interesse porque são usadas na medicina popular. Esses gêneros são ricos e...

Plants of the American continent with antimalarial activity

Malaria is a human parasitic disease caused by protozoa species of the Plasmodium genus. This disease has affected populations of the tropical and subtropical regions. About 500 million new cases occur annually on the world and therefore it is considered an emerging disease of important public health problem. In this context, the natural products as vegetables species have their bioactive molecules as targets f...

Polymeric Membrane Reactors

The aim of this chapter is the study of membrane reactors with polymeric membranes, particularly catalytic polymeric membranes. After an introduction where the main advantages and disadvantages of the use of polymeric membranes are summarised, a review of the main areas where they have been applied, integrated in chemical reactors, is presented. This excludes the field of bio-membranes processes, which is analy...

Simulation Study of a Dense Polymeric Catalytic Membrane Reactor with Plug-flow...

A theoretical study on a tubular membrane reactor, assuming isothermal operation, plug–flow pattern and using a dense polymeric catalytic membrane, is performed. The reactor conversion for an A⇄B equilibrium gas-phase reaction is analyzed, considering the influence of the reactants and products diffusion and sorption coefficients, the influence of the total pressure gradient and the influence of the...