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A lactate shuttle system between tumour and stromal cells is associated with po...
Pértega-Gomes, Nelma; Vizcaíno, José R.; Attig, Jan; Jurmeister, Sarah; Lopes, Carlos; Baltazar, FátimaBackground In a malignant tumour, cancer cells are embedded in stromal cells, namely cancer-associated fibroblasts (CAFs). These CAFs are now accepted as important players in cancer dynamics, being involved in tumour growth and progression. Although there are various reports on the interaction between tumour and stromal cells, the clinico-pathological significance of this cross-talk is still largely unknown. In...
Multigigabit Clock Recovery
Mário José Neves de Lima; José R. Ferreira da RochaThis dissertation purpose is the design and implementation of circuits to be used in the synchronization of high bit rate digital signals. At those rates clock recovery is done using an opne-loop structure, since the technology needed for developing closed-loop synchronisers is still not completely mature. (...)Keywords: optical communications; clock recovery; multigigabit; jitter; Gallium Arsenide monolit...
Non-stoichiometric La(1-x)NiO(3-delta) perovskites produced by combustion synth...
Colomer, María T.; Fumo, Daniel A.; Jurado, José R.; Segadães, Ana M.La(1-x)NiO(3-delta) perovskites present high metallic conductivity and Pauli-paramagnetism, and could be used as electrodes in electrochemical devices such as SOFCs, PEMFCs and MCFCs. Additionally, due to its sigma* conducting band, this material shows a very high electrocatalytic activity, particularly in oxygen reduction processes, with an efficiency comparable to that of platinum. This work describes the com...
Controlo de um robot de seis eixos usando três drives multiplexados
Costa, Nuno José R. S. Magalhães daActualmente verifica-se uma evolução tecnológica muito rápida no mundo empresarial industrial. Tentar acompanhar esta evolução constitui uma das prioridades para as empresas que, tendo em vista produzir cada vez mais e de um modo mais eficiente possível, têm que aproveitar ao máximo os recursos que já possuem instalados. No mundo da automação, mais em concreto no dos manipuladores industriais, acompanhar essa e...
Optimization of dense multi-wavelength optical communication systems (WDM)
António Luís Jesus Teixeira; José R. Ferreira da RochaIn this work, two main ideas were observed: The linear propagation, typically NRZ and the nonlinear propagation, typically RZ. However distinct, and normally taken in the academic and company environments as concurrent, they start to mix joining the benefits and the techniques to create more robust systems. (...)keywords: WDM; Wavelength division multiplexing; solitons; DST; Dispersion supported transmissi...
Optimisation of preamplified optical receivers for very high bit rates
Paulo Miguel N. Pereira Monteiro; José R. Ferreira da RochaThis thesis is concerned with design, optimisation and realisation of optical preamplified receivers appropriate for high capacity optical telecommunication systems. A range of post-detection filters appropriate for multigigabit return-to-zero (RZ) signalling inherent in high speed optical communication systems were investigated. (...)keywords: optical receivers; optical systems; optical solitons; signal p...
Immune and inflammatory responses to Leishmania amazonensis isolated from diffe...
Souza,Valderes L de; Veras,Patrícia ST; Welby-Borges,Marcus; Silva,Tânia MC; Leite,Bruna R; Ferraro,Rodrigo B; Meyer-Fernandes,José R; Barral,AldinaLeishmania amazonensis causes different diseases depending on the host and parasitic virulence factors. In this study, CBA mice were infected with L. amazonensis isolates from patients with localized (Ba125), diffuse cutaneous (Ba276) or visceral leishmaniasis (Ba109). Mice infected with Ba125 and Ba276 progressed rapidly and lesions displayed an infiltrate rich in parasitized macrophages and were necrotic and ...
Variáveis biométricas da cana-de-açúcar fertilizada com resíduos orgânico e ind...
Nobile,Fabio O. de; Galbiatti,João A; Muraishi,Reginaldo I; Araujo,José RO uso agrícola de resíduos orgânicos e industriais é uma alternativa de aproveitamento como fertilizante e fonte de matéria orgânica ao solo. Neste sentido, o objetivo deste trabalho foi avaliar o uso do composto de lixo e biofertilizante como fonte de nutrientes, e o resíduo do processamento da bauxita como corretivo da acidez do solo, para a cultura da cana-de-açúcar (cana-planta), irrigada com água potável e...
Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., Araliaceae, e...
Rocha,Fábio F.; Almeida,Cláudio S.; Santos,Rafael T. dos; Santana,Suely A.; Costa,Elson A.; Paula,José R. de; Vanderlinde,Frederico A.The plant Hydrocotyle umbellata L., Araliaceae (water pennywort), is widely used in Brazilian folk medicine to reduce anxiety. This work investigates the anxiolytic-like effects of the ethanol extract from H. umbellata subterraneous parts as well as the extract's other putative central nervous system effects that could justify its common use. Oral dosing of the extract (0.3 and 1 g/kg) clearly showed an anxioly...
Dissolution test of herbal medicines containing Passiflora sp.
Costa,Ane R. T.; Alves,Suzana F.; Conceição,Edemilson C. da; Garrote,Clévia F. D.; Paula,José R.; Bara,Maria Teresa F.The dissolution test is an essential tool to assess the quality of herbal medicines in the solid dosage form for oral use. This work aimed to evaluate the dissolution behavior of three herbal medicines in the form of capsules and tablet containing Passiflora, produced with powder or dried extract. Assay of total flavonoids and dissolution methods were validated and obtained results allowed the quantification of...
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