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Identification of the new variant QepA3, a plasmid-mediated quinolone resistanc...
Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Félix, David; Ferreira, EugéniaObjectives: The efflux pump QepA confers decreased susceptibility to hydrophilic fluoroquinolones (e.g., norfloxacin, ciprofloxacin, and enrofloxacin). In this study, we characterized the third variant, named qepA3, collected from an Escherichia coli isolate in Portugal. Methods: INSRA6015 was isolated in 2005 from the urine of a 77-year-old female patient hospitalized at the Hospital Fernando Fonseca, Portugal...
Zoonotic potential of multidrug resistant Escherichia coli clonal groups in Por...
Jones-Dias, Daniela; Clemente, Lurdes; Manageiro, Vera; Themudo, Patrícia; Albuquerque, Teresa; Francisco, Ana Patrícia; Louro, DeolindaObjectives: Multidrug-resistant (MDR) plasmids together with clonal dissemination of resistant isolates are possibly the most successful combination of factors contributing to the spread of antibiotic resistance genes. Our aim was to identify clones associated with multidrug-resistance among human and dolphin isolates, in order to evaluate zoonotic potential and risk. Methods: Sixty two MDR human Escherichia co...
Multilocus Sequence Typing of Vancomycin-Resistant Enterococcus faecium isolate...
Ramos, Sónia; Jones-Dias, Daniela; Caniça, Manuela; Capelo-Martinez, José Luís; Igrejas, Gilberto; Poeta, PatríciaVancomycin-resistant enterococci (VRE) first appeared in the late 1980s in a few European countries. In the last two decades, however, vancomycin-resistant Enterococcus faecium (VREfm) as became an emergent and challenging nosocomial problem. Specific clonal groups of E. faecium show an enhanced capacity to disseminate in the nosocomial setting. These strains can be assigned to distinct clonal groups or complex...
Accessing the molecular basis of transferable quinolone resistance in Escherich...
Caniça, Manuela; Jones-Dias, Daniela; Francisco, Ana Patrícia; Manageiro, Vera; Ferreira, EugéniaBackground: Salmonella and Escherichia coli resistant to quinolones frequently arise in animals, being easily transferred to humans through the food chain, which can ultimately lead to the development of untreatable infectious diseases. The aim of the present study was to investigate the presence of PMQR determinants among Salmonella spp and E. coli from food-producing animals and derivative food products. Meth...
Diversity of β-lactamase-encoding genes in Escherichia coli strains isolated fr...
Clemente, Lurdes; Correia, Ivone; Albuquerque, Teresa; Geraldes, Margarida; Matos, Filipa; Themudo, Patrícia; Manageiro, Vera; Jones-Dias, DanielaA rapid development of plasmid-mediated resistance to extended-spectrum cephalosporins has been observed in Enterobacteriaceae worldwide, predominantly due to the dissemination of extended-spectrum beta-lactamases (ESBL) and plasmid-mediated AmpC beta-lactamases (PMAB). The aim of the present study was to evaluate the extension of ESBL- and PMAB-producing E. coli strains isolated from different animal origins ...
Occurrence of extended-spectrum beta-lactamases in Salmonella enterica strains ...
Clemente, Lurdes; Correia, Ivone; Themudo, Patrícia; Albuquerque, Teresa; Manageiro, Vera; Jones-Dias, Daniela; Ferreira, Eugénia; Caniça, ManuelaSalmonella enterica is a zoonotic bacteria transmitted through the food chain and isolates harbouring extended-spectrum beta-lactamases (ESBLs) have emerged worldwide during the last decade, with the CTX-M group being particularly important. The aim of the present study was to determine the antimicrobial susceptibility of S. enterica strains isolated from broilers and food of animal origin and to characterize E...
Multilocus Sequence Typing for characterization of potential risk ESBLs-produci...
Ramos, Sónia; Caniça, Manuela; Igrejas, Gilberto; Jones-Dias, Daniela; Capelo-Martinez, José Luís; Poeta, PatríciaInfections caused by Escherichia coli harboring extended-spectrum beta-lactamases (ESBL) have a tremendous impact on public health, because of treatment complications. ESBL-producing E. coli are increasingly reported in healthy food-producing animals that can spread to humans either by direct contact or, more importantly, through the food chain. Here we describe a molecular survey aimed at determining the popul...
Identification of the new variant QepA3, a plasmid-mediated quinolone resistanc...
Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Félix, David; Ferreira, EugéniaThe efflux pump QepA confers decreased susceptibility to hydrophilic fluoroquinolones (e.g., norfloxacin, ciprofloxacin, and enrofloxacin). In this study, we characterized the third variant, named qepA3, collected from an Escherichia coli isolate in Portugal. INSRA6015 was isolated in 2005 from the urine of a 77-year-old female patient hospitalized at the Hospital Fernando Fonseca, Portugal. Susceptibility test...
Zoonotic potential of multidrug resistant Escherichia coli clonal groups in Por...
Jones-Dias, Daniela; Clemente, Lurdes; Manageiro, Vera; Themudo, Patrícia; Albuquerque, Teresa; Francisco, Ana Patrícia; Louro, DeolindaMultidrug-resistant (MDR) plasmids together with clonal dissemination of resistant isolates are possibly the most successful combination of factors contributing to the spread of antibiotic resistance genes. Our aim was to identify clones associated with multidrug-resistance among human and dolphin isolates, in order to evaluate zoonotic potential and risk. Sixty two MDR human Escherichia coli isolates were rand...
Epidemiology and zoonotic potential of Escherichia coli CTX-M-15-producing isol...
Caniça, Manuela; Clemente, Lurdes; Jones-Dias, Daniela; Manageiro, Vera; Themudo, Patrícia; Albuquerque, Teresa; Francisco, Ana PatríciaBackground: The recent spread of plasmid-located CTX-M-ESBL-encoding genes is a serious threat to the clinical efficacy of expanded-spectrum cephalosporins. This study proposes to identify the epidemiology of plasmid-mediated CTX-M-encoding genes between an Escherichia coli strain isolated from a dolphin and several E. coli strains of human origin and, explain the responsible mechanism and reservoirs of current...
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