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Sources of hepatic triglyceride accumulation during high-fat feeding in the hea...
Delgado, T. C.; Pinheiro, D.; Caldeira, M.; Castro, M. M. C. A.; Geraldes, C. F. G. C.; López-Larrubia, P.; Cerdán, S.; Jones, J. G.Hepatic triglyceride (HTG) accumulation from peripheral dietary sources and from endogenous de novo lipogenesis (DNL) was quantified in adult Sprague-Dawley rats by combining in vivo localized 1H MRS measurement of total hepatic lipid with a novel ex vivo 2H NMR analysis of HTG 2H enrichment from 2H-enriched body water. The methodology for DNL determination needs further validation against standard methodologie...
Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis o...
Delgado, T. C.; Barosa, C.; Castro, M. M. C. A.; Geraldes, C. F. G. C.; Bastos, M.; Baptista, C.; Fagulha, A.; Barros, L.; Mota, A.; Carvalheiro, M.The contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after 2H2O ingestion by Bayesian analysis of the position 2 and 5 2H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide. Six controls and 10 kidney transplant (KTx) patients with cyclosporine A (CsA) immunosuppressant therapy were studied. Seven KTx patients were lean and euglyc...
Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat
Sena, C. M.; Barosa, C.; Nunes, E.; Seiça, R.; Jones, J. G.Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had higher fasting plasma insulin (219 ± 50 versus 44 ± 14 pmol/l, P < 0.002) and glucose (9.2 ± 2.3 versus 5.5 ± 0.5 mmol/l, P < 0.025). GK rats showed impaired glucose tolerance (IPGTT 2 h p...
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