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Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering
Pereira, D. R.; Canadas, Raphael F.; Correia, Joana Silva; Marques, A. P.; Reis, R. L.; Oliveira, Joaquim M.It has been shown that hydrogel bilayered scaffolds combining cartilage- and bone-like layers are most advantageous for treating osteochondral defects. In this study, it is proposed the use of low acyl gellan gum (LAGG) for developing bilayered hydrogel scaffolds for osteochondral tissue engineering. The cartilage-like layer of the GG-based bilayered hydrogel scaffolds is composed of LAGG (2 wt%). By adding a 2...
Comunicar sem barreiras. Camões - Repositório Institucional da Universidade Aut...
Lopes, Catarina Figueirinha; Antunes, Joana; Silva, Marta LourençoAo longo de vinte e oito anos de existência a Universidade Autónoma de Lisboa tem acompanhado o desenvolvimento das tecnologias da informação e comunicação assim como as transformações sociais, culturais e económicas que têm vindo a operar mudanças significativas no processo de comunicação científica. A criação de políticas, nacionais e internacionais relativas ao acesso aberto ao conhecimento, sustentadas pel...
Prática de ensino supervisionada e trabalho de investigação : as mesas sensoria...
Matos, Joana SilvaO presente relatório constitui uma apreciação crítico-reflexiva sobre as aprendizagens efetuadas no âmbito da prática de ensino supervisionada. As dinamizações, em grupo e individuais, realizadas em contextos de Educação Pré-escolar e de 1º Ciclo do Ensino Básico e as respectivas reflexões permitiram a construção de conhecimento fundamentais ao desempenho profissional. O trabalho de investigação, realizado num ...
Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffold...
Yan, Leping; Correia, Joana Silva; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; Oliveira, Joaquim M.; Oliveira, A. L.Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyo...
Development of nanofiber-reinforced hydrogel scaffolds for nucleus pulposus reg...
Thorvaldsson, A.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Gatenholm, P.; Walkenström, P.In this work a new method is presented to efficiently produce hydrogel scaffolds reinforced with nanofibers to show enhanced mechanical properties and improved structural integrity. The method is based on a combination of air brush spraying of a hydrogel and electrospinning of nanofibers. With air brush spraying the controllability is enhanced and the potential for scale-up increased. The developed method was u...
Hydrogels in acellular and cellular strategies for intervertebral disc regenera...
Pereira, D. R.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterial...
Diverse physical growth trajectories in institutionalized portuguese children b...
Martins, Carla; Belsky, Jay; Marques, Sofia; Baptista, Joana; Silva, Joana; Mesquita, Ana Raquel Marcelino; Castro, Filipa; Sousa, Nuno; Soares, IsabelThe authors would like to thank the students involved in the data collection and coding, and especially the children, caregivers, and other institutional staff who participated in the study. Funding from Fundação para a Ciência e Tecnologia. ; Objective: To identify and analyze diverse longitudinal trajectories of physical growth of institutionalized children and their relation to child, family, and institutio...
Migration of “bioabsorbable” screws in ACL repair. How much do we know? a syste...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...
Pereira, H.; Correia, Joana Silva; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; Oliveira, Joaquim M.Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...
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