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Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons...
João, Bessa; Morais, Mónica; Marques, Fernanda; Pinto, Luísa; Palha, Joana Almeida; Sousa, NunoThere is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. Neuronal morphology and expression of plasticity-related molecules were examined in the NAc of rats ...
Late Wisconsinan Glacial Geomorphology of the Kent Interlobate Complex, Ohio, USA
Santos, João BessaThe northern sector of the Kent Interlobate Complex, created by twomajor ice lobes of the Laurentide Ice Sheet during late Wisconsinan times, dominates theglacial landscape of northeast Ohio. The geomorphology of this impressive complex revealsthe presence of large hummocks, kettle lakes and substantial esker chains. The esker chains,usually smaller than 1.3 km long, run parallel to the interlobate complex geog...
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevan...
Palha, Joana Almeida; Santos, Nadine Correia; Marques, Fernanda Cristina Gomes de Sousa; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, NunoSchizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that ...
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