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Comparison of [3,4-13C2] glucose as a tracer for glucose turnover by nuclear m...
Jin, Eunsook S.; Jones, John G.; Burgess, Shawn C.; Merritt, Matthew E.; Sherry, A. Dean; Malloy, Craig R.A recently introduced tracer, [3,4-13C2] glucose, was compared to the widely used tracer, [6,6-2H2]glucose, for measurement of whole-body glucose turnover. The rate of glucose production (GP) was measured in rats after primed infusions of [3,4-13C2]glucose, [6,6-2H2]glucose, or both tracers simultaneously followed by a constant infusion of tracer(s) over 90 min. Blood glucose was purified and converted into mon...
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxe...
Jin, Eunsook S.; Jones, John G.; Merritt, Matthew; Burgess, Shawn C.; Malloy, Craig R.; Sherry, A. DeanA triple-tracer method was developed to provide absolute fluxes contributing to endogenous glucose production and hepatic tricarboxylic acid (TCA) cycle fluxes in 24-h-fasted rats by 2H and 13C nuclear magnetic resonance (NMR) analysis of a single glucose derivative. A primed, intravenous [3,4-13C2]glucose infusion was used to measure endogenous glucose production; intraperitoneal 2H2O (to enrich total body wat...
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