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Síndromes de Falência Medular Hereditários — Seis Casos Clínicos

Os Síndromes de Falência Medular Hereditários são um grupo heterogéneo de doenças, que se caracterizam pela produção reduzida de uma ou mais linhagens hematopoiéticas pela medula óssea e consequentes citopenias no sangue periférico. Associam-se a um variado número de malformações congénitas e a maioria são entidades «pré-malignas».A propósito de seis casos, os autores tecem algumas considerações sobre as caract...

Regeneration strategies in the central nervous system : drug-loaded nanoparticl...

Unlike fish, amphibia and even mammalial peripheral nerves, human central nervous system (CNS) axons have a very limited regeneration capability and do not spontaneously re-grow if lesioned. After damage or disruption, for instance caused by brain/ spinal cord injury (SCI) or stroke, a cascade of cellular and biochemical reactions occurs around the lesion site that creates a harsh environment for axons to regen...

Monitorization of alveolar deposited surface area of nanoparticles and ultrafin...

Nanotechnology is an important emerging industry with a projected annual market of around one trillion dollars by 2015. It involves the control of atoms and molecules to create new materials with a variety of useful functions. Although there are advantages on the utilization of these nano-scale materials, questions related with its impact over the environment and human health must be addressed too, so that pote...

Defining the structure of DPCA models and its impact on process monitoring and ...

Dynamic Principal Component Analysis (DPCA) is an extension of Principal Component Analysis (PCA), developed in order to add the ability to capture the autocorrelative behavior of processes, to the existent and well-known PCA capability for modeling cross-correlation between variables. The simultaneous modeling of the dependencies along the “variable” and “time” modes, allows for a more compact and rigorous des...

Caracterização da desdentação parcial numa amostra populacional de uma Faculdad...

Interactions between Schwann and olfactory ensheathing cells with a starch/poly...

Spinal cord injury (SCI) represents a major world health problem. Therefore it is urgent to develop novel strategies that can specifically target it. We have previously shown that the implantation of starch-based scaffolds (SPCL) aimed for spine stabilization on SCI animals leads to motor skills improvements. Therefore, we hypothesize that the combination of these scaffolds with relevant cell populations for SC...

Tenogenic potential of human stem cells from the amniotic fluid and adipose tissue

Tendons are highly prone to injury and the intrinsic hypocellularity and hypovascularity make their natural healing extremely slow and inefficient when severed damaged. Surgical repair with grafts is common but unsuccessful in a long term basis. The development of tissue engineering strategies based on stem cells explores a natural endogenous system of regeneration with potential for tendon application. We prop...

Aligned silk-based 3-D architectures for contact guidance in tissue engineering

An important challenge in the biomaterials field is to mimic the structure of functional tissues via cell and extracellular matrix (ECM) alignment and anisotropy. Toward this goal, silk-based scaffolds resembling bone lamellar structure were developed using a freeze-drying technique. The structure could be controlled directly by solute concentration and freezing parameters, resulting in lamellar scaffolds with ...

Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles i...

Spinal cord injuries (SCI) still remain a major challenge in current biomedical research. In spite of several advances in the understanding of its mechanisms there has not been an equal significant translation into the clinics. As a result, there is no effective treatment that can overcome the biochemical and cellular adverse reactions that lead to a chronic severely impaired condition. One of the first opportu...

Biodistribution and preliminary therapeutic potential of CMCht/PAMAM dendrimer ...

The development of drug delivery systems (DDS) for targeted intracellular delivery of therapeutic agents has been attracting great deal of attention. In traumatic central nervous system conditions, where therapies have been revealing to be highly inneficient and non-specific, these targeted DDS could be highly beneficial. We have previously shown in vitro studies where the carboxymethylchitosan (CMCht)/ poly(am...