Encontrados 154 documentos, a visualizar página 1 de 16

Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy to enhance the first step of neurogenesis, proliferation of neural stem cells (NSC). In this work, we have studied...

Thyroid dysfunction and amiodarone

Although most patients remain clinically euthyroid, some develop amiodarone-induced hyperthyroidism (HPEAI) or hypothyroidism (HPOAI). The authors present a retrospective analysis of ten patients with amiodarone-induced thyroid dysfunction. Six patients were female and mean amiodarone intake was 17.7 months. HPOIA was more common (six patients). From all the patients with HPEAI, two had type 2, one had type 1, ...

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to...

Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitoch...

Antineutrophil cytoplasmatic antibody positive systemic vasculitis in a patient...

As necessidades dos pais de crianças hospitalizadas na área metropolitana do Porto

Imported African histoplasmosis by Histoplasma capsulatum var. duboisii in an H...

Objectives: African histoplasmosis caused by the fungus Histoplasma capsulatum var. duboisii, is a rare endemic mycosis occuring in western and central regions of sub-Saharian Africa. For unknown reasons, although HIV infection and H. capsulatum var. duboisii coexist in Africa, this coinfection remains rare. In Europe, diagnosed cases of African histoplasmosis are all imported. We describe a case of African his...

Effects of temperature and salinity on nitrate uptake by green macroalgae

Temperature, salinity and the availability of dissolved inorganic nutrients are amongst the most important abiotic factors driving macroalgae produstions in estuarine and coastal ecosystems.

Impact of tillage system on arbuscular mycorrhiza fungal communities in the soi...

A more diverse arbuscular mycorrhiza (AM) fungal community should be more versatile and resilient to variation in environmental conditions over space and time. To evaluate the effect of no-till and conventional tillage systems, AM fungal diversity was assessed as part of a long term field experiment by sequencing of DNA, extracted from soil, that encoded the large ribosomal sub-unit and was obtained by nested-P...

Effect of tillage and crop on arbuscular mycorrhiza

Large-scale inoculation with arbuscular mycorrhizal fungi (AMF) is generally impractical in most regions and we have little understanding of the factors that determine inoculation success. Nevertheless, the ability to take full advantage of indigenous AMF for sustainable production needs to be developed within cropping systems. We used part of a long-term field experiment to understand the influence of tillage ...

Impact of soil tillage and land use on soil organic carbon decline under Medite...

Soils under Mediterranean climate conditions frequently have low to very low levels of soil organic matter (SOM), as a result of low biomass production under the predominantly rainfed conditions and the intensive tillage operations commonly practiced. In order to assess both short and long-term impacts of soil tillage and land use on soil organic carbon, two sets of experiments were performed. One consisted in ...