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Naloxone inhibits nicotine-induced receptor current and catecholamine secretion...
Tomé, Angelo R.; Izaguirre, Victor; Rosário, Luís M.; Ceña, Valentín; González-García, CarmenNicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells. Naloxone inhibited nicotine-induced CA secretion, as detected by an on-line real-time electrochemical technique, in a dose-dependent manner (IC50=29 [mu]M). In voltage-clamped chromaffin cells, nicotine (10 [mu]M) evoked an average peak inward current of -...
Data: 2001
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Origem: Estudo Geral - Universidade de Coimbra
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