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In vivo biofunctional evaluation of hydrogels for disc regeneration
Reitmaier, Sandra; Kreja, Ludwika; Gruchenberg, Katharina; Kanter, Britta; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Perugini, V.Purpose Regenerative strategies aim to restore the original biofunctionality of the intervertebral disc. Different biomaterials are available, which might support disc regeneration. In the present study, the prospects of success of two hydrogels functionalized with anti-angiogenic peptides and seeded with bone marrow derived mononuclear cells (BMC), respectively, were investigated in an ovine nucleotomy model. ...
Investigation of different hydrogels for nucleus replacement : a biomechanical ...
Reitmaier, Sandra; Wolfram, Uwe; Ignatius, Anita; Wilke, Hans-Joachim; Martín-Martínez, José M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Hydrogels are considered promising for disc regeneration strategies. However, it is currently unknown whether the destruction of the natural interface between nucleus and surrounding structures caused by nucleotomy and an inadequate annulus closure diminishes the mechanical competence of the disc. To clarify these mechanisms and to evaluate whether hydrogels are able to restore the biomechanical behaviour of th...
The effect of different defects and hydrogels for nucleus replacements on the b...
Reitmaier, Sandra; Wolfram, U.; Wilke, Hans-Joachim; Ignatius, Anita; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Schmidt, HendrikPublicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Hydrogels offer unique opportunities for regenerative strategies of the intervertebral disc. A nucleotomy necessary for the implantation of hydrogels, however, disrupts the annulus integrity and destroys natural interfaces in the disc. To clarify whether hydrogels can restore the mechanical competence of the disc a...
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