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The dynamics, kinetics and reversibility of protein adsorption onto the surface...
Alves, Catarina M.; Reis, R. L.; Hunt, J. A.Dynamic contact angle (DCA) analysis was used to investigate the kinetics and dynamics of protein interactions in a time-dependent manner for a group of organic natural-based surfaces during their initial contact with aqueous and protein solutions. Starch-based biomaterials were used to analyze the influence different materials with different surfaces had on the adsorption, desorption and configuration of prote...
An in vivo study of the host response to starch-based polymers and composites s...
Marques, A. P.; Reis, R. L.; Hunt, J. A.Implant failure is one of the major concerns in the biomaterials field. Several factors have been related to the fail but in general these biomaterials do not exhibit comparable physical, chemical or biological properties to natural tissues and ultimately, these devices can lead to chronic inflammation and foreign-body reactions. Starch-based biodegradable materials and composites have shown promising propertie...
The effect of starch-based biomaterials on leukocyte adhesion and activation in...
Marques, A. P.; Reis, R. L.; Hunt, J. A.Leukocyte adhesion to biomaterials has long been recognised as a key element to determine their inflammatory potential. Results regarding leukocyte adhesion and activation are contradictory in some aspects of the material’s effect in determining these events. It is clear that together with the wettability or hydrophilicity/hydrophobicity, the roughness of a substrate has a major effect on leukocyte adhesion. Bo...
Cytokine secretion from mononuclear cells cultured in vitro with starch-based p...
Marques, A. P.; Reis, R. L.; Hunt, J. A.The cytokine network is one of the major controlling systems of the inflammatory process, driving the magnitude and duration of the host response against invading microorganisms, foreign materials, or altered internal stimuli. Pro- and antiinflammatory cytokines were quantified after in vitro culture of a mixed population of monocytes/macrophages and lymphocytes with biodegradable polymers. Different blends of ...
Natural origin degradable materials : the barrier or the passage through the im...
Marques, A. P.; Hunt, J. A.; Reis, R. L.Biodegradable materials perhaps hold much of the future potential for many biomedical applications due to their advantages when compared to non degradable materials, both in terms of their foreign body reaction and in their gradual elimination and therefore replacement. The stimulus or source of a tissue reaction is always present with non degradable biomaterials and might be the queue for chronic inflammation ...
Preliminary study on human protein adsorption and leukocyte adhesion to starch-...
Alves, C. M.; Reis, R. L.; Hunt, J. A.In this study, the adsorption of human serum albumin (HSA), fibronectin (FN) and vitronectin (VN) onto the surface of novel biodegradable materials was evaluated by immunostaining. Specifically, polymeric blends of corn starch with cellulose acetate (SCA), ethylene vinyl alcohol copolymer (SEVA-C), and polycaprolactone (SPCL) were immersed in unitary and competitive systems; that is, binary and more complex pro...
Evaluation of the potential of starch-based biodegradable polymers in the activ...
Marques, A. P.; Reis, R. L.; Hunt, J. A.The inflammatory response resulting from the implantation of a medical device may compromise its performance and efficiency leading, in certain cases, to the failure of the implant. Thus, the assessment of the behavior of inflammatory cells in vitro, constitutes a key feature in the evaluation of the adverse potential, or not, of new promising biomaterials. The objectives of this study were to determine whether...
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