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Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activit...
Gomes, André R.; Cunha, Paulo; Nuriya, Mutsuo; Faro, Carlos J.; Huganir, Richard L.; Pires, Euclides V.; Carvalho, Ana Luísa; Duarte, Carlos B.Glutamate receptor phosphorylation has been implicated in several forms of modulation of synaptic transmission. It has been reported that protein kinase A (PKA) can phosphorylate the 03B1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR4 on Ser842, both in vitro and in vivo. Here, we studied the regulation of GluR4 phosphorylation and intracellular trafficking by PKA and by metabotrop...
Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit o...
Carvalho, Ana Luísa; Kameyama, Kimihiko; Huganir, Richard L.Recent studies have suggested that protein phosphorylation of glutamate receptors may play an important role in synaptic transmission. Specifically, the phosphorylation of AMPA receptors has been implicated in cellular models of synaptic plasticity. The phosphorylation of the glutamate receptor 1 (GluR1) subunit of AMPA receptors by protein kinase A (PKA), protein kinase C (PKC), and Ca2+/calmodulin-dependent p...
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