Encontrados 6 documentos, a visualizar página 1 de 1
Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...
Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, GilBackground. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...
Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...
Moniz, Sónia; Martinho, Olga; Pinto, Filipe; Sousa, Bárbara; Loureiro, Claúdia; Oliveira, Maria José; Moita, Luis Ferreira; Honavar, MrinaliniThe gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...
Downregulation of RKIP is associated with poor outcome and malignant progressio...
Martinho, Olga; Granja, Sara Costa; Jaraquemada, Teresa; Caeiro, Cláudia; Gonçalves, Vera M.; Honavar, Mrinalini; Costa, Paulo; Damasceno, MargaridaMalignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis ...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Duodenal Angiomyolipoma
Povo, Ana; Interna Complementar Cirurgia Geral – Departamento de Cirurgia Geral, Hospital Pedro Hispano – ULS Matosinhos, PortugalAngiomyolipoma is a rare benign mesenchymal tumor. Usually located in the kidney, with an incidence of 0.3-3%. Extra-renal angiomyolipomas are extremely rare, with not much more than fifty cases having been described. We report a case of a healthy 50 year-old man, who presented with episodes of melena. Routine blood tests showed a hypochromic and microcytic anemia. An endoscopy showed an extrinsic lesion compre...
Estudo retrospectivo da doença de Creutzfeldt-Jakob diagnosticada no norte de P...
Silva,Ana Martins; Pires,Manuel Melo; Leite,Antonio J Bastos; Honavar,Mrinalini; Mendes,Alexandre; Correia,Manuel; Nora,Manuel; Silva,Mário RuiINTRODUÇÃO E OBJETIVO: Descrição das características demográficas, clinicas e neuropatológicas de 11 doentes com doença de Creutzfeldt-Jakob (DCJ). MÉTODO: Revisão clínica e neuropatológica de doentes com DCJ diagnosticados entre 1993 e 2002 em hospitais do Norte de Portugal. RESULTADOS: Foram identificados 11 doentes (4 do sexo feminino; idade média de início dos sintomas, 64 anos; média de duração da doença, ...
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