Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2011 ; Embryonic stem (ES) cells are characterized by their self-renew and pluripotency properties – the stemness state. A complex gene regulatory network (GRN), with three core transcription factors, NANOG, OCT4 and SOX2 (NOS network), underlies this state, but despite extensive work on this GRN, little ...
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