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Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: t...
Rolo, Anabela P.; Palmeira, Carlos M.; Holy, Jon M.; Wallace, Kendall B.The goal of this investigation was to determine whether chenodeoxycholic acid (CDCA)-induced apoptosis is prevented by ursodeoxycholic acid (UDCA) or tauroursodeoxycholic acid (TUDC) and to characterize the involvement of mitochondria in the process. Cultured human HepG2 cells were treated in a dose- and time-dependent protocol in order to establish a sufficiently low exposure to CDCA that causes apoptosis but ...
Data: 2004
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Origem: Estudo Geral - Universidade de Coimbra
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