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Optimal glucose and inoculum concentrations for production of bioactive molecul...
Serrano, Nadja F. G.; Rodrigues, L. R.; Hokka, Carlos O.; Sousa, Cristina P.; Teixeira, J. A.; Mussatto, Solange I.The production of antimicrobial metabolites by Paenibacillus polymyxa RNC-D was assessed. Two process variables, glucose and inoculum concentrations, were evaluated at different levels (5–40 g L−1, and at φ r = 2.5–5.0 %, respectively), and their effects on biomass formation, minimal inhibitory concentration (MIC) against Escherichia coli, and surface tension reduction (STR) were studied. When the fermentation ...
Ácido clavulânico e cefamicina c: uma perspectiva da biossíntese, processos de ...
Oliveira,Jaine H. H. Luiz de; Granato,Ana Claudia; Hirata,Daniela B.; Hokka,Carlos O.; Barboza,Marlei; Trsic,MilanThe present article reviews different aspects of the chemistry of two widely used β-lactam antibiotics Clavulanic Acid and Cephamycin C. The article discusses important details of the biosynthesis of these compounds, their action mechanism and, principally, the methods employed in their isolation and purification, in accordance with the available literature. Despite the large quantity of available articles...
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