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Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating ...
Pereira, Ana L.; Pereira, António J.; Maia, Ana R.R.; Drabek, Ksenija; Sayas, C. Laura; Hergert, Polla J.; Lince-Faria, Mariana; Matos, IrinaCLASPs are widely conserved microtubule plus-end–tracking proteins with essential roles in the local regulation of microtubule dynamics. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present, which is required for mitotic spindle assembly by regulating microtubule dynamics at the kinetochore. In mammals, however, only CLASP1 has been directly implicated in cell division, despite the existence ...
Kinetochores Use a Novel Mechanism for Coordinating the Dynamics of Individual ...
VandenBeldt, Kristin J.; Barnard, Rita M.; Hergert, Polla J.; Meng, Xing; Maiato, Helder; McEwen, Bruce F.Chromosome alignment during mitosis is frequently accompanied by a dynamic switching between elongation and shortening of kinetochore fibers (K-fibers) that connect kinetochores and spindle poles [1, 2]. In higher eukaryotes, mature K-fibers consist of 10–30 kinetochore microtubules (kMTs) whose plus-ends are embedded in the kinetochore [1-3]. A critical and long-standing question is how the dynamics of individ...
The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somat...
Maiato, Helder; Hergert, Polla J.; Moutinho-Pereira, Sara; Dong, Yimin; VandenBeldt, Kristin J.; Rieder, Conly L.; McEwen, Bruce F.Drosophila melanogaster is a widely used model organism for the molecular dissection of mitosis in animals. However, despite the popularity of this system, no studies have been published on the ultrastructure of Drosophila kinetochores and kinetochore fibers (K-fibers) in somatic cells. To amend this situation, we used correlative light (LM) and electron microscopy (EM) to study kinetochores in cultured Drosoph...
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