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Variations of the soft tissue thicknesses external to the ribs in Pectus Excava...

Rodrigues, PL; Direito-Santos, B; Moreira, AH; Fonseca, JC; Pinho, AC; Rodrigues, NF; Henriques-Coelho, T; Correia-Pinto, J; Vilaça, JL

BACKGROUND: Surgical repair of pectus excavatum (PE) has become more popular due to improvements in the minimally invasive Nuss procedure. The pre-surgical assessment of PE patients requires Computerized Tomography (CT), as the malformation characteristics vary from patient to patient. OBJECTIVE: This work aims to characterize soft tissue thickness (STT) external to the ribs among PE patients. It also presents ...


Variations of the soft tissue thicknesses external to the ribs in Pectus Excava...

Rodrigues, PL; Direito-Santos, B; Moreira, AH; Fonseca, JC; Pinho, AC; Rodrigues, NF; Henriques-Coelho, T; Correia-Pinto, J; Vilaça, JL

BACKGROUND: Surgical repair of pectus excavatum (PE) has become more popular due to improvements in the minimally invasive Nuss procedure. The pre-surgical assessment of PE patients requires Computerized Tomography (CT), as the malformation characteristics vary from patient to patient. OBJECTIVE: This work aims to characterize soft tissue thickness (STT) external to the ribs among PE patients. It also presents ...

Data: 2013   |   Origem: Repositório Comum

Neuregulin1/ErbB system: importance in the control of cardiovascular function

Lopes-Conceição, L; Dias-Neto, M; Fontes-Sousa, AP; Mendes-Ferreira, P; Maia-Rocha, C; Henriques-Coelho, T; de Keulenaer, G; Leite-Moreira, AF

The family of Neuregulins (NRG), growth factors like epidermal growth factor, is known to induce growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. This family comprises four members, being NRG1 the most largely studied, particularly at the cardiovascular level. The biological effects of NRG1 in the adult heart are mediated by the tyrosine kinase receptors ErbB. In the adult h...


Moderate exercise training provides left ventricular tolerance to acute pressur...

Moreira-Gonçalves, D; Henriques-Coelho, T; Fonseca, H; Ferreira, RM; Amado, F; Leite Moreira, A; Duarte, JA

The present study evaluated the impact of moderate exercise training on the cardiac tolerance to acute pressure overload. Male Wistar rats were randomly submitted to exercise training or sedentary lifestyle for 14 wk. At the end of this period, the animals were anaesthetized, mechanically ventilated, and submitted to hemodynamic evaluation with biventricular tip pressure manometers. Acute pressure overload was ...


Current pathophysiological concepts and management of pulmonary hypertension

Lourenço, AP; Fontoura, D; Henriques-Coelho, T; Leite-Moreira, AF

Pulmonary hypertension (PH), increasingly recognized as a major health burden, remains underdiagnosed due mainly to the unspecific symptoms. Pulmonary arterial hypertension (PAH) has been extensively investigated. Pathophysiological knowledge derives mostly from experimental models. Paradoxically, common non-PAH PH forms remain largely unexplored. Drugs targeting lung vascular tonus became available during the ...


Comparison of different methods of heart rate entropy analysis during acute ano...

Gonçalves, H; Henriques-Coelho, T; Rocha, AP; Lourenço, AP; Leite-Moreira, A; Bernardes, J

Acute life-threatening situations are particularly critical when superimposed on chronic diseases. The objective of this study was the assessment of heart rate (HR) dynamics during episodes of acute anoxia superimposed on a rat model of chronic pulmonary hypertension. In 10 adult Wistar rats, five weeks after pulmonary hypertension induction with Monocrotaline, we analysed eight 1-min HR segments, during episod...


Diastolic tolerance to systolic pressures closely reflects systolic performance...

Leite-Moreira, AF; Lourenço, AP; Roncon-Albuquerque R, Jr.; Henriques-Coelho, T; Amorim, MJ; Almeida, J; Pinho, P; Gillbert, TC

In animal experiments, elevating systolic pressures induces diastolic dysfunction and may contribute to congestion, a finding not yet translated to humans. Coronary surgery patients (63 ± 8 years) were studied with left ventricular (LV) pressure (n = 17) or pressure-volume (n = 3) catheters, immediately before cardiopulmonary bypass. Single-beat graded pressure elevations were induced by clamping the ascending ...


Neonatal pneumomediastinum and the spinnaker-sail sign

Correia-Pinto, J; Henriques-Coelho, T

A male infant was born at 40 weeks of gestation by vacuum-assisted vaginal delivery. Mild respiratory distress with expiratory grunting and subcostal retraction was noted 1 hour after birth. Arterial oxygen saturation remained at more than 95% without the administration of supplemental oxygen. Chest radiography performed 6 hours after birth (Panel A) showed the spinnaker-sail sign, consisting of a large, wedge-...


Analysis of heart rate variability in a rat model of induced pulmonary hyperten...

Gonçalves, H; Henriques-Coelho, T; Bernardes, J; Rocha, AP; Brandão-Nogueira, A; Leite-Moreira, A

Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine, wa...


Endoscopic closure of transmural bladder wall perforations

Lima, E; Rolanda, C; Osório, L; Pêgo, JM; Silva, D; Henriques-Coelho, T; Carvalho, JL; Bergström, M; Park, PO; Mosse, CA; Swain, P; Correia-Pinto, J

BACKGROUND: Traditionally, intraperitoneal bladder perforations caused by trauma or iatrogenic interventions have been treated by open or laparoscopic surgery. Additionally, transvesical access to the peritoneal cavity has been reported to be feasible and useful for natural orifice translumenal endoscopic surgery (NOTES) but would be enhanced by a reliable method of closing the vesicotomy. OBJECTIVE: To assess ...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia