Encontrados 6 documentos, a visualizar página 1 de 1
Guidelines for diagnostic and treatment of gastric adenocarcinoma (Digestive Ca...
Brito, Donzília; Especialista em Cirurgia Geral – IPO - Porto - Portugal; Raimundo, Ana; Especialista em Oncologia Médica – IPO - Porto - Portugal. ; .
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer
Baptista, Tiago; Graça, Inês; Sousa, Elsa J.; Oliveira, Ana Isabel; Costa, Natália R.; Costa-Pinheiro, Pedro; Amado, Francisco; Henrique, RuiHistone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation. SIRT1, which may act either as tumor suppressor or oncogene, reduces H2A.Z levels in cardiomyocytes, via proteasome-mediated degradation, and this mechanism might be impaired in prostate cancer cells due to sirtuin 1 downregulation. Thus, we aimed...
Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer
Pértega-Gomes, Nelma; Vízcaíno, Ramón; Gouveia, Carlos; Jerónimo, Carmen; Henrique, Rui M.; Lopes, Carlos; Baltazar, FátimaINTRODUCTION: Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate. In a previous study we described overexpression of MCT2 in prostate carcinoma raising the hypothesis of using MCT2 as a possible biomarker in prostate cancer. With the present study we aimed to compare the pattern of expression of MCT2 and alpha-methylacyl-CoA...
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated wit...
Pértega-Gomes, Nelma; Vízcaíno, Ramón; Gonçalves, Vera M.; Pinheiro, Céline; Silva, Joana; Pereira, Helena; Monteiro, Pedro; Henrique, Rui M.BACKGROUND. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown.The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 a...
Biological activities of Portuguese propolis: protection against free radical-i...
Valente, Maria J.; Baltazar, Ana F.; Henrique, Rui; Estevinho, Leticia M.; Carvalho, M.This study reports for the first time the biological properties of Portuguese propolis. The antioxidant potential of propolis samples from Bornes (Northeast) and Fundão (Centre) regions of Portugal was evaluated by their ability to inhibit the 2,20-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative hemolysis and lipid peroxidation in human erythrocytes. Bornes and Fundão propolis strongly protect...
Evaluation of immunoexpression and MDR1 promoter methylation levels in prostati...
Moura, Inês; Costa, Vera L.; Pais, Irene; Ribeiro, Franclim R.; Henrique, Rui; Jerónimo, CarmenOs objectivos deste estudo foram: (1) Determinar os níveis de metilação do promotor do MDR1 em tecido prostático com adenocarcinoma (CaP), neoplasia intraepitelial prostática de alto grau (HGPIN), hiperplasia benigna (BPH) e tecido morfologicamente normal (MNP). (2) Correlacionar os níveis de metilação com a imunoexpressão da gp-P. Os nossos resultados demonstram que a hipermetilação do MDR1 constitui um mecani...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||