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Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chela...
Ferreira, Miguel Filipe Moreira Marques; Mousavi, Bibimaryam; Ferreira, Paula M. T.; Martins, Catarina; Helm, Lothar; Martins, José A.Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the...
In vivo MRI assessment of a novel GdIII-based contrast agent designed for high ...
Sousa, Paulo Loureiro de; Livramento, João Bruno; Helm, Lothar; Merbach, André E.; Même, William; Doan, Bich-Thuy; Beloeil, Jean-ClaudeGd3L is a trinuclear Gd3+ complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene-diethylenetriamine- N,N,NPrimeNPrime-tetraacetate moieties). Thanks to its appropriate size, the presence of two inner sphere water molecules and a fast water exchange, Gd3L has remarkable proton relaxivities a...
Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in ...
Torres, Suzana; Prata, Maria I. M.; Santos, Ana C.; André, João P.; Martins, José A.; Helm, Lothar; Tóth, Éva; García-Martín, Maria L.The recently reported amphiphilic chelate, [Gd(EPTPAC16)(H2O)]2-, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect of sonication on the aggregate size was characterized by dynamic light scattering and relaxometry, indicating the presence of premicellar aggregates and an overall dec...
H5EPTPACH2OH: Synthesis, Relaxometric Characterization and 1H NMR Spectroscopic...
Torres, Susana; Martins, José A.; André, João P.; Pereira, Giovannia A.; Kiraly, Robert; Brücher, Ernö; Helm, Lothar; Tóth, ÉvaThe synthesis and characterization of a new metal chelator, 4-(S)-hydroxymethyl-3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid (H5EPTPACH2OH), is reported. Protonation constants for the ligand H5EPTPACH2OH and for the previously reported H5EPTPAC16 have been determined by potentiometry, which reveals that both ligands display slightly higher protonation constants relative to that of the ligand DTPA5-...
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