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Chitosan/polyester-based scaffolds for cartilage tissue engineering : assessmen...
Silva, M. L. Alves da; Crawford, Aileen; Mundy, Jenifer; Correlo, V. M.; Sol, P.; Bhattacharya, Mrinal; Hatton, Paul V.; Reis, R. L.; Neves, N. M.Naturally derived polymers have been extensively used in scaffold production for cartilage tissue engineering. The present work aims to evaluate and characterize extracellular matrix (ECM) formation in two types of chitosan-based scaffolds, using bovine articular chondrocytes (BACs). The influence of these scaffolds’ porosity, as well as pore size and geometry, on the formation of cartilagineous tissue was stud...
Evaluation of extracellular matrix formation in polycaprolactone and starch-com...
Silva, Marta L. Alves da; Crawford, Aileen; Mundy, Jenifer; Martins, Albino; Araújo, J. V.; Hatton, Paul V.; Reis, R. L.; Neves, N. M.Cartilage defects are a major health problem. Tissue engineering has developed different strategies and several biomaterial morphologies, including natural-based ones, for repairing these defects. We used electrospun polycaprolactone (PCL) and starch-compounded PCL (SPCL) nanofiber meshes to evaluate extracellular matrix (ECM) formation by bovine articular chondrocytes (BACs). The main aim of this work was to e...
A cartilage tissue engineering approach combining starch-polycaprolactone fibre...
Oliveira, João T.; Crawford, Aileen; Mundy, Jenifer; Moreira, A. R.; Gomes, Manuela E.; Hatton, Paul V.; Reis, R. L.In the present work we originally tested the suitability of corn starch-polycaprolactone (SPCL) scaffolds for pursuing a cartilage tissue engineering approach. Bovine articular chondrocytes were seeded on SPCL scaffolds under dynamic conditions using spinner flasks (total of 4 scaffolds per spinner flask using cell suspensions of 0.5×106 cells/ml) and cultured under orbital agitation for a total of 6 weeks. Pol...
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