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Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 su...
Hafner, Angela V.; Dai, Jing; Gomes, Ana P.; Xiao, Chun-Yang; Palmeira, Carlos M.Cardiac failure is a leading cause of age-related death, though its root cause remains unknown. Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP). Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding si...
Data: 2010
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Origem: Estudo Geral - Universidade de Coimbra
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