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In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero...
Cortes, HC; Muller, N; Boykin, D; Stephens, CE; Hemphill, AThe in vitro effects of 4 arylimidamides (DB811, DB786, DB750 and DB766) against the proliferative tachyzoite stage of the apicomplexan parasite Besnoitia besnoiti were investigated. These four compounds had been shown earlier to exhibit in vitro activities in the nanomolar range against the related apicomplexans Neospora caninum and Toxoplasma gondii. Real-time-PCR was used to assess B. besnoiti intracellular ...
Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterizat...
Marcelino, E; Martins, TM; Morais, JB; Nolasco, S; Cortes, H; Hemphill, A; Leitão, A; Novo, CExp Parasitol. 2011 Oct;129(2):164-74. Epub 2011 Jul 3. Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling. Marcelino E, Martins TM, Morais JB, Nolasco S, Cortes H, Hemphill A, Leitão A, Novo C. Source Instituto de Investigação Cientifica Tropical, CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Av. da Universidade Té...
In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazol...
CORTES, H. C. E.; MUELLER, N.; ESPOSITO, M.; LEITÃO, A.; NAGULESWARAN, A.; HEMPHILL, A.Nitazoxanide (NTZ) and its deacetylated metabolite tizoxanide (TIZ) exhibit considerable in vitro activity against Besnoitia besnoiti tachyzoites grown in Vero cells. Real-time-PCR was used to assess B. besnoiti tachyzoite adhesion, invasion, and intracellular proliferation in vitro. A number of NTZ-derivatives, including Rm4822 and Rm4803, were generated, in which the thiazole-ring-associated nitro-group was r...
Isolation of Besnoitia besnoiti from infected cattle in Portugal
Cortes, H.C.E.; Reis, Y.; Waap, H.; Vidal, R.; Soares, H.; Marques, I.; Pereira da Fonseca, I.; Fazendeiro, I.; Ferreira, M.L.; Caeiro, V.; Shkap, V.Abstract Besnoitia besnoiti, an obligate intracellular protozoan parasite belonging to the phylum apicomplexa, is the causative agent of bovine besnoitiosis. Besnoitiosis is responsible for significant losses in the cattle industry of Africa and Mediterranean countries due to the high morbidity rate, abortion and infertility in males. The acute stage of disease is associated with the proliferative forms (tachyz...
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