Encontrados 2 documentos, a visualizar página 1 de 1
Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxici...
Guerreiro, P. S.; Fernandes, A. S.; Costa, J. G.; Castro, M.; Miranda, J. P.; Oliveira, N. G.Pharmacological inhibition of DNA repair is a promising approach to increase the effectiveness of anticancer drugs. The chemotherapeutic drug doxorubicin (Dox) may act, in part, by causing oxidative DNA damage. The base excision repair (BER) pathway effects the repair of many DNA lesions induced by reactive oxygen species (ROS). Methoxyamine (MX) is an indirect inhibitor of apurinic/apyrimidinic endonuclease 1 ...
Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...
Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||