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Reshaping higher education systems in the MENA region: the contribution of remo...
Salah, R. M.; Alves, Gustavo R.; Guerreiro, P.Learning is not only happening in school or university; it is also an important aspect of the daily life that allows students to remain in their biological and physical environment helping to reshape it, by applying what they have learnt. Today, the higher education sector is a part of important strategies used by countries in order to foster their development. Despite its geographical location, i.e. its closen...
Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxici...
Guerreiro, P. S.; Fernandes, A. S.; Costa, J. G.; Castro, M.; Miranda, J. P.; Oliveira, N. G.Pharmacological inhibition of DNA repair is a promising approach to increase the effectiveness of anticancer drugs. The chemotherapeutic drug doxorubicin (Dox) may act, in part, by causing oxidative DNA damage. The base excision repair (BER) pathway effects the repair of many DNA lesions induced by reactive oxygen species (ROS). Methoxyamine (MX) is an indirect inhibitor of apurinic/apyrimidinic endonuclease 1 ...
Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...
Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...
Os tufos calcários das áreas de Estói, Loulé e ribeira das Mercês (Algarve, Por...
Guerreiro, P.; Cunha, Lúcio; Ribeiro, C.; Candeias, A.Nesta comunicação tentaremos estabelecer os principais tipos de fácies apresentadas pelos tufos desta área do Algarve Central, articulando os mesmos com os potenciais paleoambientes de formação. Os principais tipos de fácies identificadas correspondem a fácies detríticas (conglomerado e tufos pulverulentos) e de optimum de acumulação (tufo biohérmico), sendo que os primeiros podem corresponder às fases iniciais...
A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17b
Fuentes, J.; Guerreiro, P. M.; Modesto, Teresa; Rotllant, J.; Canario, Adelino V. M.; Power, DeborahEstradiol (E2) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hormone (PTH)-related protein (PTHrP) has been shown to be calciotropic in fish, we hypothesized that the two hormones could be mediating the same process. Sea bream (Sparus auratus) ju...
Stimulation of cortisol release by the N terminus of teleost parathyroid hormon...
Rotllant, J.; Guerreiro, P. M.; Anjos, Liliana; Redruello, Begoña; Canario, Adelino V. M.; Power, DeborahThe mode of action of PTHrP in the regulation of sea bream (Sparus auratus) interrenal cortisol production was studied in vitro using a dynamic superfusion system. Piscine (1–34)PTHrP (10−6–10−11 m) stimulated cortisol production in a dose-dependent manner. The ED50 of (1–34)PTHrP was 2.8 times higher than that of (1–39)ACTH, and maximum increase in cortisol production in response to 10−8 m of (1–34)PTHrP was a...
Effects of salinity challenge on the endocrine control of osmoregulation and ca...
Guerreiro, P. M.; Fuentes, J.; Flik, G.; Canario, Adelino V. M.; Power, DeborahThe gilthead sea bream (Sparus auratu) is a marine species often found in coastal lagoons, experimenting episodic exposures to both brackish and hypersaline environments. However, little is known about the underlying endocrine mechanisms controlling osmoregulation in this and in most marine species. This study aimed at characterising some of the endocrine basis of sea bream osmoregulation, with emphasis on calc...
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