Encontrados 10 documentos, a visualizar página 1 de 1
Five-membered iminocyclitol a-glucosidase inhibitors: Synthetic,biological scre...
Guerreiro, L; Carreiro, E; Fernandes, L; Cardote, T; Moreira, R; Caldeira, A Teresa; Guedes, R; Burke, A JThe design and synthesis of a small library of pyrrolidine iminocyclitol inhibitors with a structural similarity to 1,4-dideoxy-1,4-imino-D-arabitol (DAB-1) is reported. This library was specifically designed to gain a better insight into the mechanism of inhibition of glycosidases by polyhydroxylated pyrrolidines or iminocyclitols. Pyrrolidine-3,4-diol 15a and pyrrolidine-3,4-diol diacetate 15b had emerged as ...
Tuned liquid dampers simulation for earthquake response control of buildings
Novo, T.; Varum, H.; Teixeira-Dias, F.; Rodrigues, H.; Silva, M. J. Falcão; Costa, A. Campos; Guerreiro, L.This paper is focused on the study of an earthquake protection system, the Tuned Liquid Damper (TLD), which can, if adequately designed, reduce earthquake demands on buildings. This positive effect is accomplished taking into account the oscillation of the free surface of a fluid inside a tank (sloshing). The behaviour of an isolated Tuned Liquid Damper, subjected to a sinusoidal excitation at its base, with di...
Estudo comparativo, aleatorizado, em dupla ocultação, de orlistat versus placeb...
Castro, JJ; Dias, T; Chambel, P; Carvalheiro, M; Correia, LG; Guerreiro, L; Marques, O; Medina, JL; Nobre, E; Nunes, JS; Pereira, MC; Polónia, JINTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 center...
Arte Nova em Aveiro e sua relação com o Adobe
Oliveira, C.; Varum, H.; Guerreiro, L.O movimento Art Nouveau surgiu no final do século XIX com o desenvolvimento da era industrial e traduz-se pela representação do movimento com recurso a elementos naturais para ornamentação. Foi um fenómeno súbito e de curta duração que se iniciou em Bruxelas e se propagou para outros países onde adquiriu um carácter distinto e particular adaptando-se às condições estéticas de cada país. Em Portugal, este estilo...
Esterification of fatty acids to biodiesel over polymers with sulfonic acid groups
Caetano, CS; Guerreiro, L; Fonseca, I; Ramos, A; Vital, J; Castanheiro, JEThe esterification of palmitic acid with methanol was studied using poly(vinyl alcohol) cross-linked with sulfosuccinic acid (SSA) and polystyrene cross-linked with divinylbenzene with sulfonic acid groups, as catalysts, at 60 ºC. It was observed that the PVAmatrixes with sulfonic acid groups were more active than the polystyrene ones. With the most active polymeric matrix (PVA_SSA40), an almost 90% equilibrium...
Estudo Comparativo, Aleatorizado, em Dupla Ocultação, de Orlistat Versus Placeb...
Castro, JJ; Dias, T; Chambel, P; Carvalheiro, M; Correia, LG; Guerreiro, L; Marques, O; Medina, JL; Nobre, E; Silva Nunes, J; Pereira, MC; Polónia, JINTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 center...
R&D on control of vibrations under covicocepad during 2007-2008
Barros, R.C.; Baratta, A.; Corbi, O.; Braz César, M.T.; Corbi, I.; Bairrão, R.; Guerreiro, L.; Oliveira, C.; Magonette, G.This paper provides information on the latest R&D within COVICOCEPAD project approved in the framework of Eurocores program. It addresses the use of TLD, base isolation devices, MR dampers and a hybrid technique using both devices together. Some results are provided associated with calibration of a MR damper at FEUP, as well as its inclusion in a small scale laboratory set-up with proper equations of motion of ...
Mesoporous silica containing sulfonic acid groups as catalysts for alpha-pinene...
Castanheiro, J; Guerreiro, L; Fonseca, I; Ramos, A; Vital, JThe methoxylation of a-pinene was studied over sulfonic acid-functionalized mesoporous silica (MCM-41, PMO) at 60ºC. The support functionalization was achieved by the introduction of 3-(mercaptopropyl)trimethoxysilane onto the surface of these materials either by grafting or by co-condensation. The thiol groups were oxidized to SO3H by treatment with H2O2. All the catalysts were active in the studied reaction b...
The endocrine pancreas.
Cortesão, L; Serviço de Endocrinologia Diabetes e Metabolismo, Hospital de Egas Moniz, Lisboa.; Saraiva, A M; Guerreiro, LThe islets of Langerhans provide energy storage and disposal, and protection from plasma glucose excursions, especially hypoglycemia. Insulin-dependent diabetes mellitus (IDDM) results from autoimmune beta-cell damage. Prevention of IDDM has already been achieved in animal investigation and some centers are now screening and treating individuals at high risk for developing IDDM. Immunosuppressive drugs can indu...
Pure autonomic failure.
Ducla-Soares, J L; Serviço de Medicina III, Hospital de Santa Maria, Lisboa.; Guerreiro, A S; Póvoa, P; Alvares, E; Guerreiro, L; Carrilho, F; Santos, MWe present the case of a 64-year-old woman who, in the past 5 years, complained of constipation/diarrhea, hyposudoresis, xerostomia and xerophthalmia, dysuria and orthostatic hypotension. Cardiovascular reflexes analysis revealed sympathetic and parasympathetic failure. Norepinephrine was markedly reduced, both lying and after tilt. Norepinephrine infusion determined a significant rise in blood pressure, allowi...
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