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Treatment of acute promyelocytic leukemia with trans-retinoic acid. Experience ...
De Lacerda, J F; Unidade de Hematologia, Universidad de Lisboa, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; Do Carmo, J A; De Moura, M CAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia that is usually associated with a fatal hemorrhagic diathesis. All trans-retinoic acid (ATRA) is an active metabolite of vitamin A that differentiates the malignant cell clone, corrects the coagulopathy, and induces complete remission in the vast majority of patients with APL. Between June 1992 and September 1993, 8 patients with...
Data: 1970
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Origem: Acta Médica Portuguesa
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