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Adhesion of adipose-derived mesenchymal stem cells to patterned protein-glycosa...
Costa, Diana Soares da; Márquez-Posadas, M. C.; Araújo, A. R.; Yang, Y.; Becher, J.; Schnabelrauch, M.; Merino, S.; Groth, T.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Proteins and glycosaminoglycans (GAGs) are the main constituents of the extracellular matrix (ECM). Until very recently, GAGs were considered as pure structural components while proteins have been associated with crucial cell signalling processes. Nowadays, it is well accepted that these two ECM components act in s...
Sulfation degree of glycosaminoglycans triggers distinct cytoskeleton organisat...
Costa, Diana Soares da; Yang, Y.; Moller, Stephanie; Groth, T.; Reis, R. L.; Pashkuleva, I.Glycosaminoglycans (GAGs) comprise the closest cellular environment: they are building elements of the ECM and can be also found on cells surface. Their biological activity depends on several parameters among which the negative charge is of prime importance[1]. This charge is generally associated with the presence of sulfate groups (-OSO3H). Sulfation is a dynamic modification: it can occur at various positions...
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