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Epigenetic and transcriptional signatures of stable versus plastic differentiat...
Schmolka, Nina; Serre, Karine; Grosso, Ana R.; Rei, Margarida; Pennington, Daniel J.; Gomes, Anita Q.; Silva-Santos, BrunoTwo distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to...
Identification of a panel of ten cell surface protein antigens associated with ...
Gomes, Anita Q.; Correia, Daniel V.; Grosso, Ana R.; Lança, Telma; Ferreira, Cristina; Lacerda, João F.; Barata, João T.; Gomes da Silva, Maria©2010 Ferrata Storti Foundation. This is an open-access paper ; Background Vγ9Vδ2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vγ9Vδ2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers that can be used as prognostic of therapeuti...
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