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Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pat...
Nunes, Ricardo; Rodrigues, Susana; Pasko, Pawel; Tyszka-Czochara, Malgorzata; Grenha, Ana; Carvalho, Isabel Saraiva dePlants from the genus Erica are used in many countries to treat several ailments. In this work we intend to evaluate the potential in vivo benefits of Erica australis L. by testing in vitro the effect induced by the plant extract when in contact with BJ fibroblasts (3 and 9 hours) and Caco-2 cells (3, 6 and 24 hours). Effects on five pathogenic microorganisms(Enterococcus faecalis, Bacillus cereus, Escherichia ...
Pullulan-based nanoparticles as carriers for transmucosal protein delivery
Dionísio, Marita; Cordeiro, Clara; Remuñán-López, Carmen; Seijo, Begoña; Costa, Ana M. Rosa da; Grenha, AnaPolymeric nanoparticles have revealed very effective in transmucosal delivery of proteins. Polysaccharides are among the most used materials for the production of these carriers, owing to their structural flexibility and propensity to evidence biocompatibility and biodegradability. In parallel, there is a preference for the use of mild methods for their production, in order to prevent protein degradation, ensur...
Pullulan-based nanoparticles: future therapeutic applications in transmucosal p...
Rodrigues, Susana; Grenha, AnaCurrent advances in the field of drug delivery are aimed at finding adequate strategies for the administration of different drugs. Transmucosal delivery is the first-line option for the systemic delivery of many drugs, including proteins, a group of molecules with recognised therapeutic potential and wide range of applications (drug and genetic therapy, immunisation, among others).
Chitosan/carrageenan nanoparticles: effect of cross-linking with tripolyphosphate
Rodrigues, Susana; Costa, Ana M. Rosa da; Grenha, AnaChitosan/carrageenan/tripolyphosphate nanoparticles were prepared by polyelectrolyte complexation/ionic gelation, the latter compound acting as cross-linker. The incorporation of the three components in the nanoparticle matrix was assessed by analytical techniques (FTIR, XPS and TOF-SIMS). Using chitosan/carrageenan nanoparticles as control, the effect of the cross-linker in the particles properties was studie...
Systemic delivery of biopharmaceuticals: parenteral forever?
Grenha, AnaThe subject of systemic delivery of biopharmaceuticals has been discussed in some occasions in Journal of Pharmacy and Bioallied Sciences, which is now in its 11th issue. The last decades have witnessed a strong biotechnological progress, making available many biopharmaceuticals with great therapeutic potential, in many cases promising an undisputed place alongside other established therapies. The meaning o...
Chitosan nanoparticles: a survey of preparation methods
Grenha, AnaThe application of macromolecules in therapy is frequently hindered by stability and/or permeation issues. These limitations have been addressed by the pharmaceutical industry through the development of suitable non-injectable drug carriers. In this context, nanoparticles have emerged as one of the most exciting tools, due to the increased surface-to-volume ratio, which provides an intimate interaction with epi...
Locust bean gum: exploring its potential for biopharmaceutical applications
Dionísio, Marita; Grenha, AnaPolysaccharides have been finding, in the last decades, very interesting and useful applications in the biomedical and, specifically, in the biopharmaceutical field. Locust bean gum is a polysaccharide belonging to the group of galactomannans, being extracted from the seeds of the carob tree (Ceratonia siliqua). This polymer displays a number of appealing characteristics for biopharmaceutical applications, amon...
Biocompatibility of chitosan carriers with application in drug delivery
Rodrigues, Susana; Dionísio, Marita; Remuñán-López, Carmen; Grenha, AnaChitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity t...
Natural carriers for application in tuberculosis treatment
Costa, Hugo; Grenha, AnaTuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticle...
Chitosan and its derivatives as nanocarriers for siRNA delivery
Al-Qadi, Sonia; Grenha, Ana; Remuñán-López, CarmenThe ability to specifically silence genes using siRNA has enormous potential for treating genetic diseases. However, siRNA instability and biodistribution issues still need to be overcome, and adequate delivery vehicles have proven indispensable in conveying siRNA to its target. Chitosan is a promising biopolymer for siRNA delivery, its interest stemming from its safety, biodegradability, mucoadhesivity, permea...
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