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Processing and characterization of chitosan microspheres to be used as template...
Grech, Jessica M. R.; Mano, J. F.; Reis, R. L.Chitosan (Ch) microspheres have been developed by precipitation method, cross-linked with glutaraldehyde and used as a template for layer-by-layer (LBL) deposition of two natural polyelectrolytes. Using a LBL methodology, Ch microspheres were alternately coated with hyaluronic acid (HA) and Ch under mild conditions. The roughness of the Ch-based crosslinked microspheres was characterized by atomic force microsc...
Chitosan beads as templates for layer-by-layer assembly and their application i...
Grech, Jessica M. R.; Mano, J. F.; Reis, R. L.Uncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release re...
Calcium-phosphate derived from mineralized algae for bone tissue engineering ap...
Oliveira, Joaquim M.; Grech, Jessica M. R.; Leonor, I. B.; Mano, J. F.; Reis, R. L.In this work, several routes are described towards obtaining pure inorganic phases derived from Coralline officinallis red algae. The scanning electron microscopy studies have shown that it becomes possible not only to eliminate the undesired organic phase, but also to preserve or tailor the red algae typical microporosity. X-ray diffraction analysis was used to investigate the phase content of the red algae be...
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