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Effects of Li+ transport and Li+ immobilization on Li+/Mg2+ competition in cell...
Layden, Brian T.; Abukhdeir, Abde M.; Williams, Nicole; Fonseca, Carla P.; Carroll, Laura; Castro, Margarita M. C. A.; Geraldes, Carlos F. G. C.Li+/Mg2+ competition has been implicated in the therapeutic action of Li+ treatment in bipolar illness. We hypothesized that this competition depended on cell-specific properties. To test this hypothesis, we determined the degree of Li+ transport, immobilization, and Li+/Mg2+ competition in lymphoblastomas, neuroblastomas, and erythrocytes. During a 50 mmol/L Li+-loading incubation, Li+ accumulation at 30 min (...
Data: 2003
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Origem: Estudo Geral - Universidade de Coimbra
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