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Metabonomics of human amniotic fluid for prenatal diagnostics
Graça, Gonçalo Miguel GomesO trabalho apresentado nesta tese teve como principais objectivos contribuir para o conhecimento da composição do líquido amniótico humano (LA), colhido no 2º trimestre de gravidez, assim como investigar possíveis alterações na sua composição devido à ocorrência de patologias pré-natais, recorrendo à metabonómica e procurando, assim, definir novos biomarcadores de doenças da grávida e do feto. Após uma introduç...
NMR metabolomics of esca disease-affected vitis vinifera cv. Alvarinho leaves
Lima, Marta; Felgueiras, Mafalda; Graça, Gonçalo; Rodrigues, João; Barros, António; Gil, Ana M.; Dias, Alberto Carlos PiresEsca is a destructive disease that affects vineyards leading to important losses in wine production. Information about the response of Vitis vinifera plants to this disease is scarce, particularly concerning changes in plant metabolism. In order to study the metabolic changes in Vitis plants affected by esca, leaves from both infected and non-affected cordons of V. vinifera cv. Alvarinho (collected in the Vinho...
Metabolite Profiling of Human Amniotic Fluid by Hyphenated Nuclear Magnetic Res...
Graça, Gonçalo; Duarte, Iola F.; Goodfellow, Brian J.; Carreira, Isabel M.; Couceiro, Ana Bela; Domingues, Maria do Rosário; Spraul, ManfredThe metabolic profiling of human amniotic fluid (HAF) is of potential interest for the diagnosis of disorders in the mother or the fetus. In order to build a comprehensive metabolite database for HAF, hyphenated NMR has been used, for the first time, for systematic HAF profiling. Experiments were carried out using reverse-phase (RP) and ion-exchange liquid chromatography (LC), in order to detect less and more p...
Aspectos da biologia do camarão Plesionika narval (Fabricius, 1787) nos Açores
Graça, Gonçalo Nuno Santos Neto daDissertação mest., Biologia Marinha, Universidade do Algarve, 2008 ; In this study, have been approached some aspects of the biology of Plesionika narval (Fabricius, 1787) around Azores Islands, with the purpose of deepening biological knowledge on the species. Data from 3 research cruises made between 1998 and 2006 in the central group of the archipelago and Princesa Alice’s sea bank were used. These surveys ...
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