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Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Mai...
Sandro, L. Pereira; Grãos, Mário; Rodrigues, Ana Sofia; Anjo, Sandra I.; Carvalho, Rui A.; Oliveira, Paulo J.; Arenas, Ernest; Ramalho-Santos, JoãoThe mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we sought to understand the effect of mitochondrial complex III inhibition during neuronal differentiation of mouse embryonic stem cells. When exposed to antimycin A, a specific complex III inhibitor, embryonic stem cells failed to differentiate into dopaminer...
The secretome of stem cells isolated from the adipose tissue and wharton jelly ...
Ribeiro, Carlos A.; Fraga, J. S.; Grãos, Mário; Neves, N. M.; Reis, R. L.; Sousa, Nuno; Salgado, A. J.; Gimble, Jeffrey M.Introduction: It is hypothesized that administration of stromal/stem cells isolated from the adipose tissue (ASCs) and umbilical cord (HUCPVCs) can ameliorate the inured CNS. However it is still not clear whether they have similar or opposite effects on primary cultures of neuronal populations. The objective of the present work was to determine if ASCs and HUCPVCs preferentially act, or not, on specific cell po...
Towards the Maturation and Characterization of Smooth Muscle Cells Derived from...
Vazão, Helena; Neves, Ricardo Pires das; Grãos, Mário; Ferreira, LinoIn this study we demonstrate that CD34+ cells derived from human embryonic stem cells (hESCs) have higher smooth muscle cell (SMC) potential than CD34− cells. We report that from all inductive signals tested, retinoic acid (RA) and platelet derived growth factor (PDGFBB) are the most effective agents in guiding the differentiation of CD34+ cells into smooth muscle progenitor cells (SMPCs) characterized by the e...
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