Encontrados 12 documentos, a visualizar página 1 de 2
Exploring bioactive properties of marine cyanobacteria Isolated from the Portug...
Costa, Margarida; Garcia, Mónica; Costa-Rodrigues, João; Costa, Maria Sofia; Ribeiro, Maria João; Fernandes, Maria Helena; Barros, PiedadeThe oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, C...
Modulation of osteoclastogenesis by antihypertensive drugs
Oliveira, Teresa; Costa-Rodrigues, João; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria HelenaDespite its rigid structure, bone is a dynamic tissue that is in constant remodeling. This process requires the action of the bone-resorbing osteoclasts and the bone-synthesing osteoblasts. One of the adverse effects attributed to some antihypertensive agents is the ability to alter normal bone metabolism. However, their effective actions on human bone cells remain to be clarified. In this work, the effects of ...
Negative modulation of human osteoclastogenesis by antiepileptic drugs
Rocha, Sara; Costa-Rodrigues, João; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria HelenaBone is constantly being molded and shaped by the action of osteoclasts and osteoblasts. A proper equilibrium between both cell types metabolic activities is required to ensure an adequate skeletal tissue structure, and it involves resorption of old bone and formation of new bone tissue. It is reported that treatment with antiepileptic drugs (AEDs) can elicit alterations in skeletal structure, in particular in ...
Envolvimento na aprendizagem da língua estrangeira : o valor pedagógico do "liv...
Fernandes, Maria HelenaRelatório de estágio de mestrado em Ensino de Inglês e de Espanhol no 3.º Ciclo do Ensino Básico e no Ensino Secundário ; Este relatório de estágio pretende documentar o projeto de investigação-ação intitulado ”Envolvimento na aprendizagem da língua estrangeira: o valor pedagógico do ‘livro de recortes’” desenvolvido no âmbito do Mestrado em Ensino de Inglês e Espanhol no 3.º Ciclo do Ensino Básico e no Ensino...
A novel hybrid material with calcium and strontium release capability
Castro, António; Almeida, José Carlos; Salvado, Isabel Miranda; Margaça, Fernanda; Fernandes, Maria HelenaThe preparation of PDMS–TEOS–CaO hybrid materials by sol–gel techniques has been widely described in previous works. Calcium nitrate is the most common source of calcium used in these preparations. However, to remove possible toxic nitrate by-products a thermal treatment is necessary at temperatures above 500 1C, which leads to the degradation of the polymeric components of the hybrids. Strontium has already sh...
Marine cyanobacteria compounds with anticancer properties: a review on the impl...
Costa, Margarida; Costa-Rodrigues, João; Fernandes, Maria Helena; Barros, Piedade; Vasconcelos, Vitor; Martins, RosárioMarine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines,...
Synthesis, characterization and antiproliferative activity on cancer cell lines...
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís; Marrucho, Isabel; Ponte, Manuel Nunes; Prudêncio, CristinaIonic Liquids (ILs) are ionic compounds that possess melting temperature below 100ºC and they have been a topic of great interest since the mid-1990s due to their unique properties. The range of IL uses has been broadened, due to a significant increase in the variety of physical, chemical and biological ILs properties. They are now used as Active Pharmaceutical Ingredients (APIs) and recent interests are focuse...
Efeitos da vancomicina, tetraciclina, tigeciclina e metronidazol na proliferaçã...
Pacheco, Ana Paula; Ferraz, Maria Pia; Coelho, Maria João; Alegrete, Nuno; Fernandes, Maria HelenaNeste estudo foram avaliados mecanismos citotóxicos de alguns antibacterianos usados nos tratamentos de infecções ósseas, nomeadamente vancomicina, tetraciclina, tigeciclina e metronidazol numa gama de concentrações de 0,005 μg/mL a 100 μg/mL. Relativamente à vancomicina não foi encontrada nenhuma evidência de citotoxicidade sobre as células MG63. A tetraciclina tem um efeito tóxico a partir da concentração de ...
Equisetum arvense
Ferraz, Maria Pia; Pereira, Ana Catarina; Lopes, Maria Ascenção; Fernandes, Maria HelenaA procura de produtos naturais para o tratamento de doenças específicas tem aumentado muitos nos últimos anos, nomeadamente aquelas direccionadas para doenças do tecido ósseo como por exemplo a osteoporose. A utilização de fitoestrogéneos, dehydroepiandroesterona (DHEA) e vitamina K2 não só é segura como tem havido resultados clínicos preliminares estatisticamente controlados que suportam a vantagem da utilizaç...
In Vitro studies of bioactive glass/polyhydroxybutyrate composites
Paiva,André Oliveira; Duarte,Maria Gabriela; Fernandes,Maria Helena Vaz; Gil,Maria Helena; Costa,Necésio GomesBioactive materials can help bone reparation and regeneration by offering support to bone growth. In vitro studies of bioactive glass/polyhydroxybutyrate composites were carried out to evaluate the influence of the composition on the bioactivity through the presence of calcium phosphate (Ca-P) on the layer formed when the substrates were immerse in simulated body fluid (SBF). The in vitro tests were carried out...
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