[abstract] ; [resumo]
Obesity is one of the greatest public health problems of the 21st century, with major consequences in diabetes, cardiovascular diseases and cancer. It is well known that the melanocortin system is an important regulator of body energy homeostasis1. In fact, the role of the melanocortin system in the regulation of energy balance at the central nervous system has been extensively studied, although melanocortins a...
[abstract] ; [resumo]
[resumo]
Melanocortin peptides and their receptors have long been known to affect the central control of food intake and body weight, thus playing a critical role in the development of obesity [1]. The melanocortin 5 receptor (MC5R) has been directly linked with lipid metabolism in peripheral tissues: MC5R deletion in mouse generates defects in sebaceous gland secretion [1] and MC5R stimulation increases fatty acid ox...
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