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ER stress response in human celular models of senescence

Matos, Liliana; Gouveia, Alexandra; Almeida, Henrique


ER stress response activation in cellular senescence

Matos, Liliana; Gouveia, Alexandra; Almeida, Henrique



Modulation of adipocyte fat mass by Melanocortin-5-Receptor

Rodrigues, Adriana; Almeida, Henrique; Gouveia, Alexandra

[abstract] ; [resumo]


Obesidade: o papel das melanocortinas na regulação da homeostasia energética

Rodrigues, Adriana; Almeida, Henrique; Gouveia, Alexandra

Obesity is one of the greatest public health problems of the 21st century, with major consequences in diabetes, cardiovascular diseases and cancer. It is well known that the melanocortin system is an important regulator of body energy homeostasis1. In fact, the role of the melanocortin system in the regulation of energy balance at the central nervous system has been extensively studied, although melanocortins a...


Melanocortin 5 Receptor plays a major role on adipocyte lipid metabolism

Rodrigues, Adriana; Almeida, Henrique; Gouveia, Alexandra


Melanocortin 5 receptor: a new player in lipid metabolism

Adriana Rodrigues; Almeida, Henrique; Gouveia, Alexandra

[abstract] ; [resumo]


Structural insights on melanocortin 5 receptor targeting to cell surface

Rodrigues, Adriana; Almeida, Henrique; Gouveia, Alexandra

[resumo]


Melanocortin signalling in fat cells

Rodrigues, Adriana; Almeida, Henrique; Gouveia, Alexandra

Melanocortin peptides and their receptors have long been known to affect the central control of food intake and body weight, thus playing a critical role in the development of obesity [1]. The melanocortin 5 receptor (MC5R) has been directly linked with lipid metabolism in peripheral tissues: MC5R deletion in mouse generates defects in sebaceous gland secretion [1] and MC5R stimulation increases fatty acid ox...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia