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Redundancy and recombination in the Echinococcus AgB multigene family : is ther...
Haag, Karen Luisa; Gottstein, Bruno; Muller, Norbert; Schnorr, André; Ayala, Francisco J.Numerous genetic variants of the Echinococcus antigen B (AgB) are encountered within a single metacestode. This could be a reflection of gene redundancy or the result of a somatic hypermutation process. We evaluate the complexity of the AgB multigene family by characterizing the upstream promoter regions of the 4 already known genes (EgAgB1-EgAgB4) and evaluating their redundancy in the genome of 3 Echinococcus...
Reduced genetic variability within coding and non-coding regions of the echinoc...
Haag, Karen Luisa; Zaha, Arnaldo; Araujo, Aldo Mellender de; Gottstein, BrunoEchinococcus multilocularis, a vulpine intestinal tapeworm, is the causative agent of alveolar echinococosis in humans, one of the most severe and lethal parasitic infections in man. To date, there is very little knowledge about the genetical polymorphism of this parasite. To assess sequence polymorphism, we analysed a sample of 33 E. multilocularis isolates from Europe, North America and Asia by PCR-SSCP follo...
Breeding systems in Echinococcus granulosus (Cestoda; Taeniidae) : selfing or o...
Haag, Karen Luisa; Araujo, Aldo Mellender de; Gottstein, Bruno; Siles-Lucas, M.; Thompson, R. C. A.; Zaha, ArnaldoWe used the PCR±SSCP method followed by sequencing in order to assess the genetic variability of coding and noncoding parts of the genome of Echinococcus granulosus (Cestoda; Taeniidae) and to test whether or not the parasite populations are mainly self-fertilizing. For this, we analysed a sample of 110 E. granulosus metacestode isolates collected from different geographical regions (Southern Brazil, Europe and...
The EG95 antigen of Echinococcus spp. contains positively selected amino acids,...
Haag, Karen Luisa; Gottstein, Bruno; Ayala, Francisco J.Echinococcosis is a worldwide zoonotic parasitic disease of humans and various herbivorous domestic animals (intermediate hosts) transmitted by the contact with wild and domestic carnivores (definitive hosts), mainly foxes and dogs. Recently, a vaccine was developed showing high levels of protection against one parasite haplotype (G1) of Echinococcus granulosus, and its potential efficacy against distinct paras...
Application of conventional and real-time fluorescent ITS1 rDNA PCR for detecti...
Cortes, Helder C.E.; Reis, Yara; Gottstein, Bruno; Hemphill, Andrew; Leitão, Alexandre; Müller, NorbertBesnoitia besnoiti, an apicomplexan protozoan parasite, is the causative agent of bovine besnoitiosis. This infection may dramatically affect body condition, and, in males, lead to irreversible infertility. While identification of clinical cases and their histopathological confirmation is relatively simple to carry out, finding subclinical forms of infection is more difficult, thus a more sensitive test for the...
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