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Tuberculose na adolescência – o que esperar

Adolescente do sexo feminino, com 14 anos de idade, institucionalizada 4 meses antes por comportamentos de risco em contexto de disfunção familiar, sem outros antecedentes patológicos relevantes. Apresentava história de febre e tosse produtiva com sete dias de evolução, associadas a anorexia, astenia, odinofagia e mialgias. Já se encontrava medicada com amoxicilina/ácido clavulânico sem melhoria. Ao exame obj...

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRAF gene which are sufficient for initiation of hyperplastic growth but not for tumor progression. The analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant B-Raf and both events were shown to cooperate in tumor cell survival. Here we provide evidence fo...

Ibuprofen prevents inflammation-induced increase in Rac1 expression and growth ...

Alternative splicing of tumour-related rac1b is regulated by upstream signallin...

The small GTPase Rac1 regulates signalling pathways controlling actin-dependent cell motility as well as gene transcription. Analternative splicing variant Rac1b is overexpressed in a subset of colorectal tumours and cooperates with mutant B-Raf to sustain tumour cellviability. The alternative splicing mechanism regulating Rac1b expression involves two antagonistic splicing factors, ASF/SF2 and SRp20. Using aRa...

The deleterious effect of missense mutations on pre-mRNA splicing

The presence of missense mutations detected during genetic testing makes it difficult to classify their pathogenic effect. It is possible that the predicted amino acid change affects protein function; however, it is also possible that a missense mutation does not act at the protein level but rather at the nucleotide level by interfering with the correct assembly of the pre-mRNA splicing machinery. In this chapt...

Alternative splicing of tumour-related Rac1b is regulated by upstream signallin...

The small GTPase Rac1 regulates signalling pathways controlling actin-dependent cell motility as well as gene transcription. An alternative splicing variant Rac1b is overexpressed in a subset of colorectal tumours and cooperates with mutant B-Raf to sustain tumour cell viability. The alternative splicing mechanism regulating Rac1b expression involves two antagonistic splicing factors, ASF/SF2 and SRp20. Using a...

Prática de ensino supervisionada em educação Pré-Escolar

O presente relatório de estágio desenvolveu-se no âmbito da unidade curricular de prática de ensino supervisionada, tendo por finalidade a obtenção do grau de mestre em educação pré-escolar. Corresponde à descrição de um trabalho desenvolvido num contexto de jardim-de-infância inserido no meio urbano, com um grupo de crianças de três, quatro e cinco anos de idade. Este trabalho procurou compreender de que forma...

Espiritualidade, cultura e práticas de enfermagem em situações terminais: estud...

Mestrado em Ciências de Enfermagem ; Master Degree in Sciences of Nursing

Oral Candida carriage of patients attending a dental clinic in Braga, Portugal

The ability of the Candida species to colonize surfaces can be considered as a risk factor for oral infection. Aims The aim of this work was to establish oral Candida carriage in patients attending a dental clinic in Braga, Portugal. Methods A total of 97 patients were analysed. Swab samples were collected, and directly cultured onto CHROMagar Candida. Representative yeasts were identified by polymerase chain ...

O conhecimento da doença de Alzheimer e do acidente vascular celebral apresenta...

Tese de mestrado, Ciências da Educação (Psicologia da Educação - Aprendizagem e Desenvolvimento no Adulto e no Idoso), Universidade de Lisboa, Faculdade de Psicologia e de Ciências da Educação, 2009 ; A doença de Alzheimer o Acidente Vascular Cerebral (AVC) são asduas patologias cerebrais mais comuns na população idosa. Oconhecimento acerca da doença de Alzheimer permite umreconhecimento dos sintomas iniciais,...