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Bonjour Tristesse. Types of residential dissatisfaction in Portugal in relation...

Most countries face chronic housing problems, which have produced countless social tensions and politico-economic opportunities. The housing question has had different characteristics, related to quantitative and qualitative issues or the urban and environmental surroundings of the housing. Between the on-going problems’ mutations and the administration responses through public policies, complications emerge: d...

Bank capital and stock performance around the subprime lending risis

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Finance from the NOVA – School of Business and Economics ; This empirical study observes the relationship between bank capital and stock performance when an unexpected negative shock materializes to bank value. The analysis covers the three months after the collapse of Lehman Brothers on the 15th September 2008, using th...

Local Array Mapping in an Autonomous Robot

This project implements an autonomous mobile robot platform that performs a series of simple reactive behaviors and adapts to local environmental conditions. Since oscillatory motion under cornered conditions appears to be an inherent characteristic of purely reactive obstacle avoidance mechanisms in autonomous robots, a robot agent will require memory to enhance overall obstacle avoidance efficiency. In this s...

Estudo temático acerca da dispersiva obra de Francisco Salgado Zenha

Este trabalho de investigação, do curso de especialização em História das Ideologias e das Utopias Contemporâneas, lembra uma figura política, cujo passado ao serviço da liberdade e da justiça, reclamou com toda a legitimidade o direito a ser recordado. No primeiro capítulo debruçamo-nos sobre Zenha enquanto estudante e dirigente académico na Universidade de Coimbra, onde foi eleito presidente da Associação Aca...

Comunidades de prática em ambientes virtuais: da teoria à experiência colaborativa

Com este artigo pretende-se apresentar uma revisão de literatura sobre o processo de construção de conhecimento em comunidades virtuais, tendo por base a teoria do construtivismo comunal. De acordo com o modelo de Gunawardena’s et al. [1], pretende-se analisar a experiência dos autores deste artigo, num Programa Doutoral, em que as ferramentas da Web 2.0 foram utilizadas para o desenvolvimento do trabalho de di...

Peripheral myopization with multifocal contact lenses dominant design in myopic...

Distinct regulation of p53-mediated apoptosis by protein kinase calpha, delta, ...

The role of individual protein kinase C (PKC) isoforms in the regulation of p53- mediated apoptosis is still uncertain. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCa, d, e or z, we showed a differential regulation of p53- mediated apoptosis by these PKC isoforms. Whereas PKCa and z had no effect on p53 activity, PKCd and e stimulated a p53-mediated mitochondria-dependent ap...

Modulation of Bax by Protein Kinase C in yeast

Modulation of bax mitochondrial insertion and induced cell death in yeast by ma...

Protein kinase Cα (PKCα) is a classical PKC isoform whose involvement in cell death is not completely understood. Bax, a major member of the Bcl-2 family, is required for apoptotic cell death and regulation of Bax translocation and insertion into the outer mitochondrial membrane is crucial for regulation of the apoptotic process. Here we show that PKCα increases the translocation and insertion of Bax c-myc (an ...

The importance of humanized yeast to better understand the role of Bcl-2 family...

The Bcl-2 protein family plays a central role in mitochondrial membrane permeabilization. This event and the ensuing release of cytochrome c are decisive in the apoptotic cascade. Therefore, a better knowledge of these processes and their regulation will probably lead to the development of novel therapeutic strategies for treatment of apoptosis-related diseases. However, the mode of action of Bcl-2 protein fami...