O principal método reconhecido pelos metrologistas para a avaliação da incerteza de medição é de facto o Guia para a Expressão da Incerteza de Medição (Guia ISO). Entretanto, devido a algumas limitações do método proposto pelo Guia ISO, a ISO desenvolveu um método suplementar para a avaliação da incerteza de medição baseado na propagação de funções de densidade de probabilidade através do método de Monte Carlo ...
The aim of this study was to motivate health professionals to avoid missed opportunities of vaccination against tetanus. In the North of Portugal, 210 cases of tetanus were reported between 1993 and 2002. Data for this study was collected from the computerised records of statutory reportable diseases (1993-2002) and written reports from local health authorities (2000-2002). Most cases occurred between 55 and 84...
The aim of this study is to provide epidemiological evidence useful to Portuguese health services dealing with prevention and treatment of malaria. Two sources of data were used: the computer database of statutory notifiable diseases and the reports of cases studied by local health authorities. The 140 cases of malaria reported between 1993 and 2002 in the North of Portugal are described. For the 26 available r...
On the 21st of June 2002, in Copenhagen, the Regional Commission for the Certification of Poliomyelitis Eradication, declared the European Region of the World Health Organization (WHO) as polio-free. The last case (not imported) of poliomyelitis in Europe had occurred in November 1998. The health impact is enormous. In Portugal, the last case of poliomyelitis caused by the wild poliovirus, had occurred in Decem...
The most practicable assay for measurement of measles IgG (mIgG) in large numbers of sera is an enzyme immunoassay (EIA). To assess how EIA results would agree with those by the gold standard method of plaque reduction neutralization (PRN) we compared the results from the two methods in 43 pairs of maternal and umbilical cord sera, and sera from the corresponding infants when aged 11 - 14 months. In maternal-co...
For the purpose of research a large quantity of anti-measles IgG working reference serum was needed. A pool of sera from five teenagers was prepared and named Alexandre Herculano (AH). In order to calibrate the AH serum, 18 EIA assays were performed testing in parallel AH and the 2nd International Standard 1990, Anti-Measles Antibody, 66/202 (IS) in a range of dilutions (from 1/50 to 1/25600). A method which co...
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