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Application of a novel oscillatory flow micro-bioreactor to the production of γ...
Reis, N.; Gonçalves, C. N.; Aguedo, Mário; Gomes, Nelma; Teixeira, J. A.; Vicente, A. A.A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by ...
Proof-of-concept of a novel micro-bioreactor for fast development of industrial...
Reis, N.; Gonçalves, C. N.; Vicente, A. A.; Teixeira, J. A.The experimental performance of a novel micro-bioreactor envisaged for parallel screening and development of industrial bioprocesses has been tested in this work. The micro-bioreactor with an internal volume of 4.5mL is operated under oscillatory flow mixing (OFM), where a controllable mixing and mass transfer rates are achieved under batch or continuous laminar flow conditions. Several batch fermentations with...
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