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Stress affects theta activity in limbic networks and impairs novelty-induced ex...

Jacinto, Luís; Reis, Joana; Dias, Nuno S.; Cerqueira, João J.; Correia, José Higino; Sousa, Nuno

Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure cou...

Data: 2013   |   Origem: CiencIPCA

Chronic stress disrupts neural coherence between cortico-limbic structures

Dias, Nuno S.; Oliveira, João Filipe; Correia, Mariana; Gama-Pereira, Filipa; Sardinha, Vanessa Morais; Lima, Ana; Oliveira, Ana Filipa

Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CU...

Data: 2013   |   Origem: CiencIPCA

Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippoca...

Lopes, A.; Torres, D. B.; Rodrigues, Ana João; Cerqueira, João; Pêgo, José M.; Sousa, Nuno; Gontijo, J. A. R.; Boer, P. A.

Studies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out a detailed morphometric analysis of the hippo...


Perceived stress in obsessive-compulsive disorder is related with obsessive but...

Morgado, Pedro; Freitas, D.; Bessa, J. M.; Sousa, Nuno; Cerqueira, João

Obsessive–compulsive disorder (OCD) is achronic psychiatric disorder characterized by recurrent intrusive thoughts and/or repetitive compulsory behaviors. This psychiatric disorder is known to be stress responsive, as symptoms increase during periods of stress but also because stressful events may precede the onset of OCD. However, only a few and inconsistent reports have been published about the stress percept...


Chronic stress disrupts neural coherence between cortico-limbic structures

Oliveira, João F.; Dias, N. S.; Correia, Mariana; Pereira, Filipa Gama; Sardinha, Vanessa Morais; Lima, Ana Raquel; Oliveira, Ana Filipa Martins

The authors would like to thank Rui Gomes for the help in the application of electrophysio- logical techniques and Luís Martins and Miguel Carneiro for the histological preparations. ; Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and ...


Stressed brain, diseased heart : a review on the pathophysiologic mechanisms of...

Pereira, Vitor H.; Cerqueira, João; Palha, Joana Almeida; Sousa, Nuno

Cardiovascular diseases are traditionally related to well known risk factors like dyslipidemia, smoking, diabetes and hypertension. More recently, stress, anxiety and depression have been proposed as risk factors for cardiovascular diseases including heart failure, ischemic disease, hypertension and arrhythmias. Interestingly, this association has been established largely on the basis of epidemiological data, d...


Stress affects theta activity in limbic networks and impairs novelty-induced ex...

Jacinto, L. R.; Reis, Joana Vanessa Santos dos; Dias, N. S.; Cerqueira, João; Sousa, Nuno

Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure cou...


Stress impact on resting state brain networks

Soares, José Miguel; Sampaio, Adriana; Ferreira, Luís Miguel; Santos, Nadine Correia; Marques, Fernanda; Palha, Joana Almeida; Cerqueira, João

Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...


Variable delay-to-signal : a fast paradigm for assessment of aspects of impulsi...

Almeida, Hugo Leite; Melo, António; Pêgo, José M.; Bernardo, Sara; Milhazes, Nuno; Borges, Fernanda; Sousa, Nuno; Almeida, Armando; Cerqueira, João

Testing impulsive behavior in rodents is challenging and labor-intensive. We developed a new behavioral paradigm-the Variable Delay-to-Signal (VDS) test-that provides rapid and simultaneous assessment of response and decision impulsivity in rodents. Presentation of a light at variable delays signals the permission for action (nose poke) contingent with a reward. 2 blocks of 25 trials at 3 s delay flank a block ...


Neudesin is involved in anxiety behavior : structural and neurochemical correlates

Novais, Ashley da Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.

Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia