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Brain activation of the defensive and appetitive survival systems in obsessive ...

Several studies have shown that basic emotions are responsible for a significant enhancement of early visual processes and increased activation in visual processing brain regions. It may be possible that the cognitive uncertainty and repeated behavioral checking evident in Obsessive Compulsive Disorder (OCD) is due to the existence of abnormalities in basic survival circuits, particularly those associated with ...

Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected wi...

Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schis...

Anticancer effect of Quercetin in Hepatocellular Carcinoma: the role of GLUT-1

Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, with rising incidence. Without specific treatment, the prognosis is very poor and diminished survival. The most effective therapy is liver transplantation and complete surgical resection, however, since only 15% of patients are candidates for such therapies, a wide range of patients are subjected to treatment with conventional therapies, and the r...

Novel ABCA3 mutations as a cause of respiratory distress in a term newborn

We report here the case of a term female newborn that developed severe respiratory distress soon after birth. She was found to be a compound heterozygote for both novel mutations in the ABCA3 gene. ABCA3 deficiency should be considered in mature babies who develop severe respiratory distress syndrome.

Polymyalgia rheumatica - always to be kept in mind

Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

INTRODUCTION: Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma. MATERIAL AND ...

Novel ABCA3 mutations as a cause of respiratory distress in a term newborn

We report here the case of a term female newborn that developed severe respiratory distress soon after birth. She was found to be a compound heterozygote for both novel mutations in the ABCA3 gene. ABCA3 deficiency should be considered in mature babies who develop severe respiratory distress syndrome.

Predicting seasonal and hydro-meteorological impact in environmental variables ...

This study focuses on the potential improvement of environmental variables modelling by using linear state-space models, as an improvement of the linear regression model, and by incorporating a constructed hydro-meteorological covariate. The Kalman filter predic- tors allow to obtain accurate predictions of calibration factors for both seasonal and hydro-meteorological components. This methodology can be used t...

Change-point analysis in environmental time series

Change-points are present in many environmental time series. Time variations in environmental data are complex and they can hinder the identification of the so-called change-points when traditional models are applied to this type of problems. In this study, it is proposed an alternative approach for the application of the change-point analysis by taking into account this data structure (seasonality and autocorr...

Metodologia estatística para a classificação das escolas secundárias em Portugal

Neste trabalho pretende-se efetuar um estudo, na área da Estatística, sobre a classificação das Escolas Secundárias (Portugal Continental e Ilhas) relativamente aos resultados alcançados pelos seus alunos nos Exames Nacionais. Tem-se como principal objetivo identificar grupos de Escolas com diferentes graus de desempenho considerando os subsistemas de ensino nacional público e privado, bem como a sua reg...