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Understanding the role of growth factors in modulating stem cell tenogenesis
Gonçalves, A. I.; Rodrigues, Márcia T.; Lee, S. J.; Atala, A.; Yoo, James; Reis, R. L.; Gomes, Manuela E.Current treatments for tendon injuries often fail to fully restore joint biomechanics leading to the recurrence of symptoms, and thus resulting in a significant health problem with a relevant social impact worldwide. Cell-based approaches involving the use of stem cells might enable tailoring a successful tendon regeneration outcome. As growth factors (GFs) powerfully regulate the cell biological response, thei...
Magnetic nanoparticles potential for stem cell functionalization
Gonçalves, A. I.; Rodrigues, Márcia T.; Santo, Vítor E.; Reis, R. L.; Gomes, Manuela E.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Stem cells have the capacity to migrate within tissues to damaged areas. The ability to remotely monitor and manipulate cells encouraging their precise positioning to desired sites for tissue regeneration would have a potential impact in tissue engineering and regenerative medicine. Cell monitoring and cell localiz...
Magnetic-responsive hydrogels for cartilage tissue engineering
Popa, Elena G.; Rodrigues, Márcia T.; Santo, Vítor E.; Gonçalves, A. I.; Reis, R. L.; Gomes, Manuela E.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The use of magnetic nanoparticles (MNPs) has been explored as an alternative approach to overcome current limitations of regenerative medicine strategies. Cell engineering approaches where MNPs are incorporated within three-dimensional constructs, such as scaffolds or hydrogels may constitute a novel and attractive...
Burns. A retrospective study of the Burn Unit of the Hospital de Santa Maria.
Henriques, A M; Unidade de Queimados, Hospital de Santa Maria, Lisboa.; Gonçalves, A I; Matos, M M; Amaral, M JA retrospective analysis was made concerning 291 admissions to the Burn Care Unit from June 1987 to March 1992, due to acute burns. Within that considered period of time there was a progressive increase in the number of admissions. Of the patients admitted, patients 177 men were and 144 women. The average age was 33.7 years. The main etiology was thermal injury. The average time of admission was 24.3 days. The ...
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